A new carbamate with cytotoxic activity from the aerial parts of Siegesbeckia pubecens.
10.1016/S1875-5364(12)60002-8
- Author:
Jia LIU
1
;
Rong CHEN
;
Yu NIE
;
Lin FENG
;
Hai-Dao LI
;
Jing-Yu LIANG
Author Information
1. Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
- Publication Type:Journal Article
- MeSH:
Antineoplastic Agents, Phytogenic;
isolation & purification;
pharmacology;
therapeutic use;
Asteraceae;
chemistry;
Carbamates;
isolation & purification;
pharmacology;
therapeutic use;
Cell Line, Tumor;
Humans;
Inhibitory Concentration 50;
Lung Neoplasms;
drug therapy;
Molecular Structure;
Phytotherapy;
Plant Components, Aerial;
chemistry;
Plant Extracts;
chemistry;
pharmacology;
therapeutic use;
Quercetin;
analogs & derivatives;
isolation & purification
- From:
Chinese Journal of Natural Medicines (English Ed.)
2012;10(1):13-15
- CountryChina
- Language:English
-
Abstract:
AIM:To study the chemical constituents of Siegesbeckia pubescens.
METHODS:The chemical constituents were isolated by extraction, crystallization and various chromatographic methods, and the chemical structures were elucidated on the basis of spectral analysis. In addition, the cytotoxic activity of compound 1 was evaluated using human lung cancer cell A 549.
RESULTS:Four compounds were obtained, and their structures were identified as (E)-3-(3-oxobut-1-enyl)phenyl dimethylcarbamate (1), ent-2-oxo-15, 16, 19-trihydroxypimar-8(14)-ene (2), 16-acetylkirenol (3), 3, 7-dimethylquercetin (4).
CONCLUSION:Compound 1 is a new carbamate, and the IC(50) in MTT method of compound 1 was 58 μg·mL(-1).
