5, 6-Dihydropyranobenzopyrone: a previously undetermined antioxidant isolated from Polygonum amplexicaule.
10.1016/S1875-5364(12)60006-5
- Author:
Mudasir A TANTRY
1
;
Mohamed M RADWAN
;
Seema AKBAR
;
Ikhlas A KHAN
Author Information
1. National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, MS 38677, United States. mtantry@olemiss.edu
- Publication Type:Journal Article
- MeSH:
Antioxidants;
chemistry;
isolation & purification;
pharmacology;
Biphenyl Compounds;
metabolism;
Coumarins;
chemistry;
isolation & purification;
pharmacology;
Molecular Structure;
Picrates;
metabolism;
Plant Extracts;
chemistry;
pharmacology;
Polygonum;
chemistry
- From:
Chinese Journal of Natural Medicines (English Ed.)
2012;10(1):28-31
- CountryChina
- Language:English
-
Abstract:
AIM:To study the chemical constituents and their bioactivity of Polygonum amplexicaule.
METHODS:The isolation of compounds was achieved by chromatographic techniques and structure of the isolates was established by UV, IR, HRESI-MS and NMR including 1D and 2D experiments.
RESULTS:Bioassay-guided fractionation of an ethanolic extract of Polygonum amplexicaule led to the isolation of a hitherto unidentified compound, 5, 6-dihydropyranobenzopyrone (1) along with nine previously known compounds (2-10). Compounds 2-10 were identified as amplexicine (2), catechin (3), rutin (4), quercetin-3-O-β-D-galactopyranoside (5), chlorogenic acid (6), galloyl glucose (7), caffeic acid (8), gallic acid (9) and scopletin (10).
CONCLUSION:Compound 1 is new. Compounds 1-10 exhibited considerable antioxidant activity in a 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging assay.
