Anticancer and antimicrobial activity of mangrove derived fungi Hypocrea lixii VB1.
10.1016/S1875-5364(12)60017-X
- Author:
B Valentin BHIMBA
1
;
D A AGNEL DEFORA FRANCO
;
Jibi Merin MATHEW
;
Geena Mary JOSE
;
Elsa Lycias JOEL
;
M THANGARAJ
Author Information
1. Department of Biotechnology, Sathyabama University, Chennai-600 119, India. bvbhimba@yahoo.co.in
- Publication Type:Journal Article
- MeSH:
Anti-Bacterial Agents;
pharmacology;
therapeutic use;
Antineoplastic Agents;
pharmacology;
therapeutic use;
Avicennia;
microbiology;
Base Sequence;
Biological Products;
pharmacology;
therapeutic use;
Cell Line, Tumor;
DNA, Fungal;
Endophytes;
Humans;
Hypocrea;
genetics;
MCF-7 Cells;
Neoplasms;
drug therapy;
Phylogeny;
Phytotherapy;
RNA, Satellite;
Rhizophoraceae;
microbiology;
Species Specificity
- From:
Chinese Journal of Natural Medicines (English Ed.)
2012;10(1):77-80
- CountryChina
- Language:English
-
Abstract:
AIM:Mangrove is one of the oldest living tree species and its leaves are among the most extensively studied botanicals in use today. Scientific research throughout the world has found evidence to support the fact that its foliar extracts have great potential against human microbial pathogens. This study highlights the isolation of foliar fungi from Rhizophora mucronata, Avicenna officialis and Avicenna marina.
METHOD:It was isolated in Sabouroud's Dextrose Agar and mass cultivation was done in Sabouroud's Dextrose broth.
RESULTS:The ethyl acetate extract showed maximum antibacterial activity which inturn checked for different concentration against bacterial pathogens and anticancer activity for Hep2 and MCF7 cell line in vitro. The DNA was isolated from the fungi and the ITS region of 5.8 s RNA was sequenced and assigned to new species as they are separated from the type strains phylogenetic neighbors by sequence similarities.
CONCLUSION:This preliminary screening of fungal endophytes revealed their potential to yield potent bioactive compounds for drug discovery programmes.
