Determination of the absolute configuration of natural products.
10.1016/S1875-5364(13)60016-3
- Author:
Ling-Yi KONG
1
;
Peng WANG
Author Information
1. State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, China. cpu_lykong@126.com
- Publication Type:Journal Article
- MeSH:
Biological Products;
chemistry;
Circular Dichroism;
Molecular Structure;
Optical Rotation;
X-Ray Diffraction
- From:
Chinese Journal of Natural Medicines (English Ed.)
2013;11(3):193-198
- CountryChina
- Language:English
-
Abstract:
Structural elucidation of natural products is always one of the most important tasks for natural product researchers in related fields. Particularly, the absolute configuration (AC), being a great challenge for natural product chemists, has attracted much attention. During the past few decades, many techniques and approaches have been developed to determine the AC of natural products, including direct (or absolute) methods, e.g. X-ray diffraction (XRD), electronic and vibrational circular dichroism (ECD and VCD), and Raman optical activity (ROA), as well as indirect (or relative) methods using a reference or a derivatizing agent with known AC, e.g. CD with empirical rules and nuclear magnetic resonance (NMR) utilizing anisotropic effects of chiral derivatizing agents. However, none of the currently applied techniques is capable of dominating AC determination, since they each have their respective limitations corresponding to the different structural features. This mini review summarizes most of the techniques and methods which are commonly used in AC assignment of natural products, or have potential application prospects, and briefly describes their principles, advantages and limitations.
