Effect of diammonium glycyrrhizinate on entecavir pharmacokinetics in rats.
10.1016/S1875-5364(13)60034-5
- Author:
Fei-Yan LI
1
;
Hai-Ping HAO
;
Kun HAO
;
Ting-Ting YAN
;
Guang-Ji WANG
Author Information
1. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Drug Interactions;
Glycyrrhizic Acid;
pharmacology;
Guanine;
analogs & derivatives;
blood;
pharmacokinetics;
Male;
Rats;
Rats, Sprague-Dawley
- From:
Chinese Journal of Natural Medicines (English Ed.)
2013;11(3):309-313
- CountryChina
- Language:English
-
Abstract:
AIM:This study was designed to explore the effects of short-term and long-term pretreatment of diammonium glycyrrhizinate (GLN) on the pharmacokinetics of entecavir (ETV) in rats.
METHODS:Male SD rats were randomized into short-term and long-term experimental groups, respectively. In the short-term experiment, the control group received saline, the low dose group received GLN 13.5 mg·kg(-1) and the high dose group received GLN 40.5 mg·kg(-1). ETV (0.09 mg·kg(-1)) was given i.g. 0.5 h after saline/GLN administration. For the long-term experiment, rats were allocated into two experimental designs. The control group received saline/ETV (0.09 mg·kg(-1)), the low dose group received GLN 13.5 mg·kg(-1)/ETV 0.09 mg·kg(-1) + GLN 13.5 mg·kg(-1), while the high dose group received GLN 40.5 mg·kg(-1)/ETV 0.09 mg·kg(-1) + GLN 40.5 mg·kg(-1); all administration was continued for 15 days. On the 16(th) day, 0.09 mg·kg(-1) ETV was administrated to all groups. Blood samples were obtained at different time points after ETV administration to determine plasma ETV concentrations.
RESULTS:Pretreatment with glycyrrhizin resulted in no significant alterations in the main pharmacokinetic parameters of ETV in the short-term and long-term administration experiments.
CONCLUSION:Diammonium glycyrrhizinate has no effect on ETV pharmacokinetics in rats.
