A pair of sulfonated diarylheptanoid epimers from Kaempferia galanga.
10.1016/S1875-5364(13)60045-X
- Author:
Fang-Lin WANG
1
;
Jian-Guang LUO
;
Xiao-Bing WANG
;
Ling-Yi KONG
Author Information
1. Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
- Publication Type:Journal Article
- MeSH:
Chromatography, High Pressure Liquid;
Diarylheptanoids;
chemistry;
isolation & purification;
Isomerism;
Plant Extracts;
chemistry;
isolation & purification;
Rhizome;
chemistry;
Zingiberaceae;
chemistry
- From:
Chinese Journal of Natural Medicines (English Ed.)
2013;11(2):171-176
- CountryChina
- Language:English
-
Abstract:
AIM:To discover new bioactive constituents from Kaempferia galanga L. (Zingiberaceae).
METHODS:The extract of K. galanga was divided into the chloroform and water-soluble portions. The latter fraction was successively subjected to column chromatography over a D101 macroporous adsorption resin, MCI, Sephadex LH-20, and preparative HPLC to obtain two compounds.
RESULTS:Two novel sulfonated diarylheptanoid epimers, namely kaempsulfonic acids A (1) and B (2), were isolated from the rhizomes of K. galanga. Their structures were established by analysis of spectroscopic data. The absolute configurations of 1 and 2 were determined by the comparison of experimental electronic circular dichroism (ECD) spectroscopy and the computational calculation method, combined with Mo2(OAc)4 induced circular dichroism (ICD).
CONCLUSION:The isolates 1 and 2 are new compounds and their absolute configurations were determined for the first time.
