Ameliorating effect of new constituents from the hooks of Uncaria rhynchophylla on scopolamine-induced memory impairment.
10.1016/S1875-5364(13)60057-6
- Author:
Suk-Chul SHIN
1
;
Dong-Ung LEE
Author Information
1. Institute of Bioconvergence Technology, Dongguk University, Gyeongju, 780-714, Korea.
- Publication Type:Journal Article
- Keywords:
Passive avoidance task;
Trans-anethole;
Uncaria rhynchophylla;
Water-maze task
- MeSH:
Animals;
Humans;
Male;
Memory;
drug effects;
Memory Disorders;
drug therapy;
Molecular Structure;
Plant Extracts;
administration & dosage;
chemistry;
isolation & purification;
Rats;
Rats, Sprague-Dawley;
Scopolamine;
adverse effects;
Uncaria;
chemistry
- From:
Chinese Journal of Natural Medicines (English Ed.)
2013;11(4):391-395
- CountryChina
- Language:English
-
Abstract:
AIM:To study the chemical constituents and their anti-amnesic effect from the hooks of Uncaria rhynchophylla.
METHODS:The isolation of compounds was performed by chromatographic techniques and their structures were identified on the basis of spectral analysis. Their ameliorating effects on scopolamine-induced memory impairment in vivo using a Morris water-maze task and passive avoidance task system were evaluated.
RESULTS:Activity-guided fractionation of the total extracts resulted in the isolation of four constituents, trans-anethole (1), p-anisaldehyde (2), estragole (3), and 3-oxo-olean-12-en-28-oic acid (4), which were found for the first time from this plant.
CONCLUSION:Compound 1 exhibited a better memory enhancing effect than tacrine, a positive agent, at the same dose in the passive avoidance test and a similar property in the water-maze test, and its action may be mediated, in part, by the acetylcholine enhancing cholinergic nervous system.
