A new Amaryllidaceae alkaloid from the bulbs of Lycoris radiata.
10.1016/S1875-5364(13)60060-6
- Author:
Sheng-Dian HUANG
1
;
Yu ZHANG
;
Hong-Ping HE
;
Shi-Fei LI
;
Gui-Hua TANG
;
Duo-Zhi CHEN
;
Ming-Ming CAO
;
Ying-Tong DI
;
Xiao-Jiang HAO
Author Information
1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
- Publication Type:Journal Article
- Keywords:
2α-Methoxy-6-O-ethyloduline;
2α-Methoxy-6-O-methyloduline;
Amaryllidaceae alkaloids;
Homolycorine-type;
Lycoris radiata
- MeSH:
Alkaloids;
chemistry;
isolation & purification;
pharmacology;
Antiviral Agents;
chemistry;
isolation & purification;
pharmacology;
Flowers;
chemistry;
Influenza A virus;
drug effects;
Lycoris;
chemistry;
Molecular Structure;
Plant Extracts;
chemistry;
isolation & purification;
pharmacology
- From:
Chinese Journal of Natural Medicines (English Ed.)
2013;11(4):406-410
- CountryChina
- Language:English
-
Abstract:
AIM:To study the Amaryllidaceae alkaloids of the bulbs of Lycoris radiata.
METHODS:The chemical constituents were isolated and purified by various chromatographic techniques, and the chemical structures were elucidated on the basis of spectroscopic methods. In addition, the antiviral activities of alkaloids 1-10 were evaluated using flu virus A.
RESULTS:One new homolycorine-type alkaloid 2α-methoxy-6-O-ethyloduline (1), together with nine known alkaloids 2α-methoxy-6-O-methyloduline (2), trispherine (3), 8-O-demethylhomolycorine (4), homolycorine (5), 9-O-demethylhomolycorine (6), oduline (7), lycorenine (8), 6α-O-methyllycorenine (9) and O-ethyllycorenine (10) were obtained.
CONCLUSION:Alkaloid 1 is a new compound, and 1-3 were major alkaloids in this plant. Alkaloids 1-3 showed weak antiviral activities against flu virus A with IC50 values of 2.06, 0.69, and 2.71 μg·mL-1 and CC50 values of 14.37, 4.79, and 80.12 μg·mL-1, respectively.
