Isolation of cytotoxic compounds from the seeds of Crataegus pinnatifida.
10.1016/S1875-5364(13)60061-8
- Author:
Ling-Zhi LI
1
;
Ying PENG
;
Chao NIU
;
Pin-Yi GAO
;
Xiao-Xiao HUANG
;
Xin-Liang MAO
;
Shao-Jiang SONG
Author Information
1. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
- Publication Type:Journal Article
- Keywords:
Crataegus pinnatifida;
Cytotoxic activity;
Norlignans
- MeSH:
Cell Line;
Cell Proliferation;
drug effects;
Crataegus;
chemistry;
Humans;
Molecular Structure;
Nerve Tissue Proteins;
chemistry;
isolation & purification;
toxicity;
Plant Extracts;
chemistry;
isolation & purification;
toxicity;
Seeds;
chemistry
- From:
Chinese Journal of Natural Medicines (English Ed.)
2013;11(4):411-414
- CountryChina
- Language:English
-
Abstract:
AIM:To study the chemical constituents and bioactivity of the seeds of Crataegus pinnatifida.
METHODS:The chemical constituents were isolated and purified by macroporous adsorptive resin D101, silica gel, and ODS column chromatography, and preparative HPLC. Their structures were elucidated on the basis of spectroscopic methods. In addition, the cytotoxic activities of compounds 1-4 were investigated on OPM2 and RPMI-8226 cells.
RESULTS:Four compounds were obtained and their structures were identified as (7S, 8S)-4-[2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-1-(hydroxymethyl)ethoxy]-3, 5-dimethoxybenzaldehyde (1), (+)-balanophonin (2), erythro-guaiacylglycerol-β-coniferyl aldehyde ether (3), buddlenol A (4).
CONCLUSION:Compound 1 is a novel norlignan, while compounds 1-4 exhibited marginal inhibition on the proliferation of OPM2 and RPMI-8226 cells.
