Two novel resin glycosides isolated from Ipomoea cairica with α-glucosidase inhibitory activity.
10.1016/S1875-5364(16)30020-6
- Author:
Jie-Hong LI
1
;
Jie-Tao PAN
1
;
Yong-Qin YIN
2
Author Information
1. Department of Traditional Chinese Medicinal Chemistry, Guangdong Pharmaceutical University, Guangzhou 510006, China.
2. Department of Traditional Chinese Medicinal Chemistry, Guangdong Pharmaceutical University, Guangzhou 510006, China. Electronic address: yongqinyin@126.com.
- Publication Type:Journal Article
- Keywords:
Ipomoea cairica;
Resin glycoside;
Simonic acid A;
α-Glucosidase
- MeSH:
Glycoside Hydrolase Inhibitors;
isolation & purification;
pharmacology;
Ipomoea;
chemistry;
Molecular Structure;
Plant Extracts;
pharmacology;
Resins, Plant;
isolation & purification;
pharmacology;
Spectrum Analysis;
alpha-Glucosidases
- From:
Chinese Journal of Natural Medicines (English Ed.)
2016;14(3):227-231
- CountryChina
- Language:English
-
Abstract:
In the present study, two new compounds from Ipomoea cairica were identified and demonstrated to have α-glucosidase inhibitory activity. They were isolated by column chromatography on silica gel and sephadex LH-20 and finally purified by prep-HPLC, with their structures being elucidated by spectroscopic methods, such as 1D- and 2D-NMR and HR-TOF-MS, and chemical methods. Compounds 1 and 2, named cairicoside A and cairicoside B, were evaluated for α-glucosidase inhibitory activity by the MTT method, with the IC50 values being 25.3 ± 1.6 and 28.5 ± 3.3 μmol·L(-1), respectively.
