Two new ortho benzoquinones from Uncaria rhynchophylla.
10.1016/S1875-5364(16)30021-8
- Author:
Qian ZHANG
1
;
Lei CHEN
1
;
Le-Jian HU
1
;
Wen-Yuan LIU
2
;
Feng FENG
3
,
4
;
Wei QU
5
Author Information
1. Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
2. Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, 210009, China.
3. Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China
4. Key Laboratory of Biomedical Functional Materials, China Pharmaceutical University, Nanjing, 210009, China. Electronic address: fengfeng@cpu.edu.cn.
5. Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China. Electronic address: weiqcpu@126.com.
- Publication Type:Journal Article
- Keywords:
Ortho benzoquinones;
Spectroscopic identification;
Uncaria rhynchophylla
- MeSH:
A549 Cells;
Antineoplastic Agents, Phytogenic;
chemistry;
pharmacology;
Benzoquinones;
isolation & purification;
pharmacology;
Drug Screening Assays, Antitumor;
Hep G2 Cells;
Humans;
Plant Extracts;
chemistry;
pharmacology;
Uncaria;
chemistry
- From:
Chinese Journal of Natural Medicines (English Ed.)
2016;14(3):232-235
- CountryChina
- Language:English
-
Abstract:
The present study was designed to determine the chemical constituents of the stems and hooks of Uncaria rhynchophylla. The chemical constituents were isolated and purified from CH2Cl2 fraction by chromatography. Their structures were elucidated by spectroscopic analyses. Their cytotoxicity was tested using MTT method. Two new ortho benzoquinones, 3-diethylamino-5-methoxy-1, 2-benzoquinone (1) and 3-ethylamino-5-methoxy-1, 2-benzoquinone (2), together with a known compound isorhynchophyllic acid (3) were isolated from U. rhynchophylla. These compounds were evaluated for their cytotoxicity against cancer cells A549, HepG2 and A2780. Compounds 1 and 2 were new ortho benzoquinones and showed weak antiproliferative activities on A549, HepG2 and A2780 cells. Compound 3 significantly inhibited the proliferation of A549, HepG2 and A2780 cells with IC50 values being 5.8, 12.8 and 11.8 µmol·L(-1), respectively.
