Chemical constituents of Solanum coagulans and their antimicrobial activities.
10.1016/S1875-5364(16)30033-4
- Author:
Xu-Jie QIN
1
,
2
;
Paul-Keilah LUNGA
1
,
3
;
Yun-Li ZHAO
4
;
Ya-Ping LIU
5
;
Xiao-Dong LUO
6
Author Information
1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650201, China
2. University of Chinese Academy of Science, Beijing 100049, China.
3. Department of Biochemistry, Laboratory of Phytobiochemistry and Medicinal Plants Study, Faculty of Science, University of Yaoundé 1, Yaoundé P. O. Box 812, Cameroon.
4. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650201, China.
5. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650201, China. Electronic address: liuyaping@mail.kib.ac.cn.
6. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650201, China. Electronic address: xdluo@mail.kib.ac.cn.
- Publication Type:Journal Article
- Keywords:
Solanum coagulans;
antimicrobial activity;
chemical constituents
- MeSH:
Anti-Infective Agents;
chemistry;
isolation & purification;
pharmacology;
Bacteria;
drug effects;
Drugs, Chinese Herbal;
chemistry;
isolation & purification;
pharmacology;
Fungi;
drug effects;
Glycosides;
chemistry;
isolation & purification;
pharmacology;
Molecular Structure;
Solanum;
chemistry
- From:
Chinese Journal of Natural Medicines (English Ed.)
2016;14(4):308-312
- CountryChina
- Language:English
-
Abstract:
The present study aimed at determining the chemical constituents of Solanum coagulans and their antimicrobial activities. The compounds were isolated by various chromatographic techniques and their structures were elucidated on the basis of extensive spectroscopic analysis, chemical methods, and comparison with reported spectroscopic data. One new phenolic glycoside, methyl salicylate 2-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside (1), together with 12 known compounds (2-13), were isolated from the aerial parts of Solanum coagulans. Compound 1 was a new phenolic glycoside, and 2-6 were isolated from Solanum genus for the first time. The antimicrobial activities of the isolated compounds were also evaluated. Compound 7 showed remarkable antifungal activity against T. mentagrophytes, M. gypseum and E. floccosum with MIC values being 3.13, 1.56 and 3.13 μg·mL(-1), respectively.
