Cranberry extract supplementation exerts preventive effects through alleviating Aβ toxicity in Caenorhabditis elegans model of Alzheimer's disease.
10.1016/S1875-5364(16)30039-5
- Author:
Hong GUO
1
,
2
;
Yu-Qing DONG
3
,
4
;
Bo-Ping YE
5
Author Information
1. School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China
2. Department of Biological Sciences, Clemson University, Clemson, SC 29634, USA.
3. Department of Biological Sciences, Clemson University, Clemson, SC 29634, USA
4. Institute for Engaged Aging, Clemson University, Clemson, SC 29634, USA. Electronic address: ydong@clemson.edu.
5. School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China. Electronic address: yebp@cpu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Aβ toxicity;
Body paralysis;
Caenorhabditis elegans;
Cranberry polyphenols;
Prevention
- MeSH:
Alzheimer Disease;
drug therapy;
genetics;
metabolism;
psychology;
Amyloid beta-Peptides;
metabolism;
toxicity;
Animals;
Caenorhabditis elegans;
drug effects;
metabolism;
Dietary Supplements;
analysis;
Disease Models, Animal;
Female;
Fruit;
chemistry;
Humans;
Male;
Memory;
drug effects;
Plant Extracts;
administration & dosage;
Vaccinium macrocarpon;
chemistry
- From:
Chinese Journal of Natural Medicines (English Ed.)
2016;14(6):427-433
- CountryChina
- Language:English
-
Abstract:
Cranberry extract (CBE) rich in polyphenols are potent to delay paralysis induced by alleviating β-amyloid (Aβ) toxicity in C. elegans model of Alzheimer's disease (AD). In order to better apply CBE as an anti-AD agent efficiently, we sought to deterrmine whether preventive or therapeutic effect contributes more prominently toward CBE's anti-AD activity. As the level of Aβ toxicity and memory health are two major pathological parameters in AD, in the present study, we compared the effects of CBE on Aβ toxicity and memory health in the C. elegans AD model treated with preventive and therapeutic protocols. Our results revealed that CBE prominently showed the preventive efficacy, providing a basis for further investigation of these effects in mammals.
