Reproductive toxicity of brazilein in ICR mice.
10.1016/S1875-5364(16)30041-3
- Author:
Zhi-Yi YUAN
1
;
Fan LEI
1
;
Yu-Shuang CHAI
1
;
Hao WU
2
;
Shuang ZHAO
1
;
Yu-Gang WANG
1
;
Tian-Shi FENG
1
;
Hui-Ying LI
1
;
Hui-Yu LI
1
;
Hong-Lei ZHAN
1
;
Dong-Ming XING
3
;
Li-Jun DU
4
Author Information
1. MOE Key Laboratory of Protein Sciences, Laboratory of Molecular Pharmacology and Pharmaceutical Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China.
2. NGM Biopharmaceuticals, Inc., South San Francisco, CA 94080, United States.
3. MOE Key Laboratory of Protein Sciences, Laboratory of Molecular Pharmacology and Pharmaceutical Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China. Electronic address: pharm@mail.tsinghua.edu.cn.
4. MOE Key Laboratory of Protein Sciences, Laboratory of Molecular Pharmacology and Pharmaceutical Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China. Electronic address: lijundu@mail.tsinghua.edu.cn.
- Publication Type:Journal Article
- Keywords:
Brazilein;
General productive toxicity;
Mice
- MeSH:
Animals;
Benzopyrans;
toxicity;
Caesalpinia;
toxicity;
Drugs, Chinese Herbal;
toxicity;
Female;
Indenes;
toxicity;
Male;
Mice;
Mice, Inbred ICR;
Pregnancy;
Reproduction;
drug effects
- From:
Chinese Journal of Natural Medicines (English Ed.)
2016;14(6):441-448
- CountryChina
- Language:English
-
Abstract:
Brazilein is an active small molecular compound extracted from Caesalpinia sappan L. with favorable pharmacological properties on immune system, cardiovascular system, and nervous system. C. sappan has been used as a traditional medicine in China for hundreds of years for various diseases. However, the general reproductive toxicity of brazilein is still unknown. The purpose of the present study was to thoroughly evaluate the general reproductive toxicity of brazilein in ICR mice to support the future drug development and modernization of this potent traditional Chinese medicine. The results showed that, although no apparent toxicity on the reproducibility of the male was observed, brazilein might cause considerable risks to the fetuses and females as indicated by the ratios of dead fetuses and reabsorptions. In conclusion, our results from the present study provided some useful insights about the safety profile of brazilein, suggesting that brazilein should be used with caution in pregnant women.
