Bofutsushosan ameliorates obesity in mice through modulating PGC-1α expression in brown adipose tissues and inhibiting inflammation in white adipose tissues.
10.1016/S1875-5364(16)30042-5
- Author:
Ying-Ying CHEN
1
,
2
;
Yan YAN
3
;
Zheng ZHAO
4
;
Mei-Jing SHI
3
;
Yu-Bin ZHANG
5
Author Information
1. State Key Laboratory of Natural Medicines, Department of Biochemistry, China Pharmaceutical University, Nanjing 210009, China
2. Shanghai Key Laboratory of Complex Prescription, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
3. State Key Laboratory of Natural Medicines, Department of Biochemistry, China Pharmaceutical University, Nanjing 210009, China.
4. Department of Pharmacy, Nanjing First Hospital, Nanjing Medical University, Nanjing 210009, China.
5. State Key Laboratory of Natural Medicines, Department of Biochemistry, China Pharmaceutical University, Nanjing 210009, China. Electronic address: ybzhang@cpu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Bofutsushosan;
Inflammation;
Obesity;
PGC-1α;
UCP1
- MeSH:
Adipose Tissue, Brown;
drug effects;
immunology;
Adipose Tissue, White;
drug effects;
immunology;
Animals;
Cytokines;
genetics;
metabolism;
Drugs, Chinese Herbal;
administration & dosage;
Energy Metabolism;
drug effects;
Female;
Humans;
Interleukin-6;
genetics;
immunology;
Mice;
Obesity;
drug therapy;
genetics;
immunology;
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha;
genetics;
immunology;
Tumor Necrosis Factor-alpha;
genetics;
immunology;
Uncoupling Protein 1;
genetics;
metabolism
- From:
Chinese Journal of Natural Medicines (English Ed.)
2016;14(6):449-456
- CountryChina
- Language:English
-
Abstract:
The inducible co-activator PGC-1α plays a crucial role in adaptive thermogenesis and increases energy expenditure in brown adipose tissue (BAT). Meanwhile, chronic inflammation caused by infiltrated-macrophage in the white adipose tissue (WAT) is a target for the treatment of obesity. Bofutsushosan (BF), a traditional Chinese medicine composed of 17 crude drugs, has been widely used to treat obesity in China, Japan, and other Asia countries. However, the mechanism underlying anti-obesity remains to be elucidated. In the present study, we demonstrated that BF oral administration reduced the body weight of obese mice induced by high-fat diet (HFD) and alleviated the level of biochemical markers (P < 0.05), including blood glucose (Glu), total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-C) and insulin. Our further results also indicated that oral BF administration increased the expression of PGC-1α and UCP1 in BAT. Moreover, BF also reduced the expression of inflammatory cytokines in WAT, such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). These findings suggested that the mechanism of BF against obesity was at least partially through increasing gene expression of PGC-1α and UCP1 for energy consumption in BAT and inhibiting inflammation in WAT.
