Novel 9, 10-dihydrophenanthrene derivatives from Eria bambusifolia with cytotoxicity aganist human cancer cells in vitro.
10.1016/S1875-5364(16)30073-5
- Author:
Rui ZHAN
1
;
Zhi-Chong WANG
1
;
Ben-Lin YIN
1
;
Ying LIU
1
;
Ye-Gao CHEN
2
Author Information
1. School of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, China.
2. School of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, China. Electronic address: ygchen48@126.com.
- Publication Type:Journal Article
- Keywords:
9, 10-Dihydrophenanthrene;
Cytotoxicity;
Erathrins A and B;
Eria bambusifolia
- MeSH:
Antineoplastic Agents, Phytogenic;
chemistry;
pharmacology;
Cell Survival;
drug effects;
Dendrobium;
chemistry;
HL-60 Cells;
Humans;
Molecular Structure;
Phenanthrenes;
chemistry;
pharmacology;
Plant Extracts;
chemistry;
pharmacology
- From:
Chinese Journal of Natural Medicines (English Ed.)
2016;14(8):621-625
- CountryChina
- Language:English
-
Abstract:
The present study was designed to identify bioactive compounds similar to those isolated from Dendrobium genus from its relative specie Eria bambusifolia. Compounds 1-10 were isolated and purified using silica gel, MCI CHP-20 gel, Sephadex LH-20, and Lichroprep RP-18 chromatography methods. Their structures were elucidated by means of extensive spectroscopic analyses. The cytotoxicity of these compounds against five human cancer cell lines was tested. Erathrins A and B (1 and 2) were new compounds, and compound 1 represented a novel carbon framework having a phenanthrene-phenylpropane unit with a dioxane moiety. Moreover, compound 1 showed selective cytotoxic activity against HL-60 cells (IC50 = 14.50 μmol·L(-1)). These results provided a basis for future development of these agents as anticancer lead compounds.
