Two new limonoids isolated from the fuits of Melia toosendan.
10.1016/S1875-5364(16)30082-6
- Author:
Qiong ZHANG
1
;
Qing-Hong ZHENG
2
;
Jing-Yu LIANG
3
;
Qing-Shan LI
2
;
Zhi-Da MIN
3
Author Information
1. Department of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China. Electronic address: zhangqiong_83@hotmail.com.
2. Department of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China.
3. Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
- Publication Type:Journal Article
- Keywords:
Antibacterial;
Limonoid;
Melia toosendan;
Meliaceae;
Oral pathogen
- MeSH:
Anti-Bacterial Agents;
chemistry;
isolation & purification;
pharmacology;
Drugs, Chinese Herbal;
chemistry;
isolation & purification;
Fruit;
chemistry;
Limonins;
chemistry;
isolation & purification;
Magnetic Resonance Spectroscopy;
Melia;
chemistry;
Molecular Structure;
Porphyromonas gingivalis;
drug effects;
growth & development;
Spectrometry, Mass, Electrospray Ionization
- From:
Chinese Journal of Natural Medicines (English Ed.)
2016;14(9):692-696
- CountryChina
- Language:English
-
Abstract:
In the present study, two new limonoids, 1α, 7α-dihydroxyl-3α-acetoxyl-12α-ethoxylnimbolinin (1) and 1α-tigloyloxy-3α-acetoxyl-7α-hydroxyl-12β-ethoxylnimbolinin (2), together with other four known limonoids (3-6), were isolated from the fruits of Melia toosendan. Their structures were elucidated by means of extensive spectroscopic analyses (NMR and ESI-MS) and comparisons with the data reported in the literature. The isolated compounds were evaluated for their antibacterial activities. Compound 4 exhibited significant antibacterial activity against an oral pathogen, Porphyromonas gingivalis ATCC 33277, with an MIC value of 15.2 μg·mL(-1). Compound 2 was also active against P. gingivalis ATCC 33277, with an MIC value of 31.25 μg·mL(-1). In conlcusion, our resutls indicate that these compounds may provide a basis for future development of novel antibiotics.
