Diversity synthesis of tetrahydroprotoberberines glycosides by combined chemical and microbial catalysis.
10.1016/S1875-5364(16)30093-0
- Author:
Hai-Xia GE
1
,
2
;
Jian ZHANG
3
;
Kun QIAN
4
;
Bo-Yang YU
5
;
Xiao-Ping CHEN
6
Author Information
1. Department of Pharmacy, Huzhou University, Huzhou 313000, China
2. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
3. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
4. Department of Pharmacy, Huzhou University, Huzhou 313000, China.
5. Department of Complex Prescription of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 211198, China. Electronic address: boyangyu59@163.com.
6. Huzhou Food and Drug Inspection Institute, Huzhou 313000, China.
- Publication Type:Journal Article
- Keywords:
Chemical demethylation;
Diversity synthesis;
Microbial glycosylation;
THPBs library
- MeSH:
Berberine Alkaloids;
chemical synthesis;
chemistry;
metabolism;
Biotransformation;
Catalysis;
Gliocladium;
metabolism;
Glycosides;
chemical synthesis;
chemistry;
metabolism;
Glycosylation;
Molecular Structure
- From:
Chinese Journal of Natural Medicines (English Ed.)
2016;14(10):783-788
- CountryChina
- Language:English
-
Abstract:
The present study was designed to construct the structurally diverse library of tetrahydroprotoberberines (THPBs) by combining the methods of chemical nonselective demethylation and microbial glycosylation. HPLC-MS/MS analyses tentatively identified 12 de-methylated and 9 glycosylated derivates of THPBs and 5 rarely oxidized glycosides of THPBs in the library. Through this effort, we achieved not only a variety of the THPBs and their glycosides but also tested the catalytic characteristics and capabilities of G. deliquescens NRRL 1086.
