Anti-tumor activity of wogonin, an extract from Scutellaria baicalensis, through regulating different signaling pathways.
10.1016/S1875-5364(17)30005-5
- Author:
Do Luong HUYNH
1
;
Neelesh SHARMA
2
;
Amit KUMAR SINGH
1
;
Simrinder SINGH SODHI
1
;
Jiao-Jiao ZHANG
1
;
Raj Kumar MONGRE
1
;
Mrinmoy GHOSH
1
;
Nameun KIM
1
;
Yang HO PARK
3
;
Dong KEE JEONG
4
Author Information
1. Laboratory of Animal Genetic Engineering and Stem Cell Biology, Department of Animal Biotechnology, Faculty of Biotechnology, Jeju National University, Jeju 63243, Republic of Korea.
2. Division of Veterinary Medicine, Faculty of Veterinary Science & Animal Husbandry, Sher-e-Kashmir University of Agricultural Sciences & Technology, R.S. Pura, Jammu 181102, India.
3. BRM Institute, Seoul 06111, Republic of Korea.
4. Laboratory of Animal Genetic Engineering and Stem Cell Biology, Department of Animal Biotechnology, Faculty of Biotechnology, Jeju National University, Jeju 63243, Republic of Korea. Electronic address: dkjeong@jejunu.ac.kr.
- Publication Type:Journal Article
- Keywords:
Anti-cancer;
Apoptosis;
Pharmacokinetics;
Signaling pathways;
Wogonin
- MeSH:
Animals;
Antineoplastic Agents, Phytogenic;
pharmacology;
therapeutic use;
DNA Adducts;
metabolism;
Drug Resistance, Neoplasm;
drug effects;
Drugs, Chinese Herbal;
pharmacology;
therapeutic use;
Flavanones;
pharmacology;
therapeutic use;
Humans;
Neoplasms;
drug therapy;
metabolism;
Phytotherapy;
Scutellaria baicalensis;
chemistry;
Signal Transduction;
drug effects
- From:
Chinese Journal of Natural Medicines (English Ed.)
2017;15(1):15-40
- CountryChina
- Language:English
-
Abstract:
Wogonin is a plant flavonoid compound extracted from Scutellaria baicalensis (Huang-Qin or Chinese skullcap) and has been studied thoroughly by many researchers till date for its anti-viral, anti-oxidant, anti-cancerous and neuro-protective properties. Numerous experiments conducted in vitro and in vivo have demonstrated wogonin's excellent tumor inhibitory properties. The anti-cancer mechanism of wogonin has been ascribed to modulation of various cell signaling pathways, including serine-threonine kinase Akt (also known as protein kinase B) and AMP-activated protein kinase (AMPK) pathways, p53-dependent/independent apoptosis, and inhibition of telomerase activity. Furthermore, wogonin also decreases DNA adduct formation with a carcinogenic compound 2-Aminofluorene and inhibits growth of drug resistant malignant cells and their migration and metastasis, without any side effects. Recently, newly synthesized wogonin derivatives have been developed with impressive anti-tumor activity. This review is the succinct appraisal of the pertinent articles on the mechanisms of anti-tumor properties of wogonin. We also summarize the potential of wogonin and its derivatives used alone or as an adjunct therapy for cancer treatment. Furthermore, pharmacokinetics and side effects of wogonin and its analogues have also been discussed.
