17-16,17-Dihydroxycyclooctatinyl-hexaketide ester from Streptomyces sp. SR107.
10.1016/S1875-5364(17)30018-3
- Author:
Meng-Yu-Jie LIU
1
;
Shan-Ren LI
1
;
L U CHUN-HUA
2
Author Information
1. Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
2. Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China. Electronic address: ahua0966@sdu.edu.cn.
- Publication Type:Journal Article
- Keywords:
17-[16,17-Dihydroxycyclooctatinyl]-hexaketide ester;
Antibacterial activity;
Diterpenes;
Streptomyces sp. SR107
- MeSH:
Anti-Bacterial Agents;
chemistry;
pharmacology;
Bacteria;
drug effects;
Diterpenes;
chemistry;
metabolism;
pharmacology;
Esters;
chemistry;
pharmacology;
Magnetic Resonance Spectroscopy;
Molecular Structure;
Streptomyces;
chemistry
- From:
Chinese Journal of Natural Medicines (English Ed.)
2016;14(12):931-933
- CountryChina
- Language:English
-
Abstract:
A new hexaketide acid esterified by the 17-hydroxyl group of 16,17-dihydroxycyclooctatin, namely 17-[16,17-dihydroxycyclooctatinyl]-hexaketide ester (1), a member of the group of rare bacterial diterpenes with a fused 5-8-5 ring system was isolated from strain Streptomyces sp. SR107. The structure was determined on the basis of its spectral data (H NMR, C NMR, H-H COSY, HSQC, HMBC, NOESY, IR and HR-ESI-MS). The antibacterial activity was also evaluated in this paper.
