Isolation and identification of two new compounds from marine-derived fungus Acremonium fusidioides RZ01.
10.1016/S1875-5364(17)30019-5
- Author:
Xiao AN
1
,
2
;
Bao-Min FENG
3
;
Gang CHEN
1
,
2
;
Shao-Fei CHEN
1
,
2
;
Hai-Feng WANG
1
,
4
;
Yue-Hu PEI
1
,
5
Author Information
1. Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China
2. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
3. School of Life Sciences and Biotechnology, Dalian University, Dalian 116622, China.
4. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: wanghaifeng0310@163.com.
5. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: peiyueh@vip.163.com.
- Publication Type:Journal Article
- Keywords:
Acremonium fusidioides;
Chemical constituent;
Fusidione;
Steroid
- MeSH:
Acremonium;
chemistry;
classification;
isolation & purification;
metabolism;
Antineoplastic Agents;
chemistry;
isolation & purification;
pharmacology;
Cell Proliferation;
drug effects;
Fermentation;
HL-60 Cells;
Humans;
Magnetic Resonance Spectroscopy;
Molecular Structure;
Seawater;
microbiology
- From:
Chinese Journal of Natural Medicines (English Ed.)
2016;14(12):934-938
- CountryChina
- Language:English
-
Abstract:
Two new compounds, (22E)-25-carboxy-8β,14β-epoxy-4α,5α-dihydroxyergosta-2,22-dien-7-one (1) and fusidione (3), along with two known compounds, 5α,8α-epidioxy ergosta-6,22-diene-3β-ol (2) and microperfuranone (4), were isolated from the fermentation products of the marine-sourced fungus Acremonium fusidioides RZ01. The structures of compounds 1 and 3 were elucidated by extensive spectroscopic methods, especially 2D NMR, and their absolute configurations were suggested on the basis of the circular dichroism spectral analysis and the NOESY data. Both new compounds showed inhibitory activity against HL-60 cells with IC values being16.6 and 44.9 μmol·L, respectively.
