Pharmacokinetics and tissue distributions of veratric acid after intravenous administration in rats.
10.1016/S1875-5364(15)30048-0
- Author:
Yu-Shuai PENG
1
;
Li-Jia LIU
1
;
Can ZHAO
1
;
Xin YANG
1
;
Chen LIU
1
;
Ru-Feng WANG
2
Author Information
1. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China.
2. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China. Electronic address: wangrufeng@tsinghua.org.cn.
- Publication Type:Journal Article
- Keywords:
Pharmacokinetics;
Tissue distribution;
Veratric acid
- MeSH:
Administration, Intravenous;
Animals;
Kidney;
metabolism;
Liver;
metabolism;
Myocardium;
metabolism;
Plant Extracts;
metabolism;
pharmacokinetics;
Ranunculaceae;
chemistry;
Rats, Sprague-Dawley;
Tissue Distribution;
Vanillic Acid;
analogs & derivatives;
metabolism;
pharmacokinetics
- From:
Chinese Journal of Natural Medicines (English Ed.)
2015;13(7):535-539
- CountryChina
- Language:English
-
Abstract:
The present study was designed to investigate the pharmacokinetics and tissue distributions of veratric acid following intravenous administration in rats. The concentrations of veratric acid in rat plasma at various times after administrated at doses of 2.5, 5, and 10 mg·kg(-1) were quantified by HPLC. The tissue distributions of veratric acid at various times after a single intravenous dose of 2.5 mg·kg(-1) were also analyzed. The plasma pharmacokinetic parameters at the three doses were as follows: t(1/2), (86.23 ± 6.83), (72.66 ± 4.10) and (71.20 ± 2.90) min; C0, (11.10 ± 1.47), (23.67 ± 1.24) and (39.17 ± 3.90) μg·mL(-1); and AUC(0→∞), (1 240.90 ± 129.14), (2 273.84 ± 132.47) and (3 516.4 ± 403.37) min·μg·mL(-1), respectively. The compound was distributed into tissues rapidly and extensively after intravenous administration and was mainly distributed into the liver, heart and kidneys.
