Identification and characterization of three new flavonoids from Rhododendron dauricum.
10.1016/S1875-5364(15)30059-5
- Author:
Xin-Wei LOU
1
;
Qing-Hua LIN
1
;
Guan-Yu ZHANG
1
;
Wen-Yuan LIU
2
,
3
;
Feng FENG
4
,
5
;
Wei QU
4
,
6
Author Information
1. Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
2. Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, 210009, China
3. Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Ministry of Education, Nanjing 210009, China.
4. Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China
5. Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing, 210009, China. Electronic address: fengfeng@cpu.edu.cn.
6. Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing, 210009, China. Electronic address: popoqzh@126.com.
- Publication Type:Journal Article
- Keywords:
Flavonoids;
Rhododendron dauricum L.;
Spectroscopic identification
- MeSH:
Flavanones;
chemistry;
isolation & purification;
Flavonoids;
chemistry;
isolation & purification;
Galactosides;
chemistry;
isolation & purification;
Glucosides;
chemistry;
isolation & purification;
Molecular Structure;
Plant Extracts;
chemistry;
Plant Leaves;
chemistry;
Quercetin;
analogs & derivatives;
chemistry;
isolation & purification;
Rhododendron;
chemistry
- From:
Chinese Journal of Natural Medicines (English Ed.)
2015;13(8):628-633
- CountryChina
- Language:English
-
Abstract:
The present study was designed to determine the major chemical constituents of the leaves of Rhododendron dauricum L. Compounds were isolated and purified by various chromatographic methods, and their structures were elucidated by physicochemical properties and spectral data. The present study identified two new C-methyl flavanones, 5, 7, 3', 5'-tetrahydroxy-6, 8-di-C-methyl flavanone (1) and 5, 4'-dihydroxy-8-C-methylflavanone-7-O-β-D-glucopyranoside (2), and one new flavonoid glycoside, quercetin-3-O-β-D-(6"-O-cinnamoyl)-galactoside (3), along with seven known compounds, including syzalterin (4), poriolin (5), farrerol-7-O-β-D-glucopyranoside (6), myrciacetin (7), quercetin-3-O-β-D-(6-p-hydroxy-benzoyl)-galactoside (8), quercetin-3-O-β-D-(6-p-coumaroyl)-galactoside (9), and 5, 7, 3', 5'-tetrahydroxyl flavanone (10). Compounds 1-3 were determined to be new flavonoids; compounds 4-6 were isolated from this species for the first time; and compounds 7-10 were reported for the first time from this genus.
