A new γ-alkylated-γ-butyrolactone from the roots of Solanum melongena.
10.1016/S1875-5364(15)30068-6
- Author:
Jing SUN
1
,
2
;
Hui-Xia HUO
1
,
2
;
Zheng HUANG
1
,
2
;
Jing ZHANG
1
,
2
;
Jun LI
3
;
Peng-Fei TU
4
Author Information
1. Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
2. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China.
3. Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China. Electronic address: drlj666@163.com.
4. Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China. Electronic address: pengfeitu@163.com.
- Publication Type:Journal Article
- Keywords:
Anti-inflammation;
Melongenolide A;
Solanaceae;
Solanum melongena;
γ-Alkylated-γ-butyrolactone
- MeSH:
4-Butyrolactone;
analogs & derivatives;
isolation & purification;
Animals;
Furans;
isolation & purification;
pharmacology;
Inflammation;
drug therapy;
metabolism;
Inhibitory Concentration 50;
Kaempferols;
isolation & purification;
pharmacology;
Lignans;
isolation & purification;
pharmacology;
Macrophages;
drug effects;
metabolism;
Mice;
Nitric Oxide;
metabolism;
Plant Extracts;
chemistry;
pharmacology;
therapeutic use;
Plant Roots;
chemistry;
RAW 264.7 Cells;
Solanum melongena;
chemistry;
Triterpenes;
isolation & purification;
pharmacology
- From:
Chinese Journal of Natural Medicines (English Ed.)
2015;13(9):699-703
- CountryChina
- Language:English
-
Abstract:
A new γ-alkylated-γ-butyrolactone, named melongenolide A (1), along with nine known compounds were obtained from the roots of Solanum melongena, and their structures were identified as melongenolide A (1), (+)-syringaresinol (2), (+)-lyoniresinol (3), 5,5'-dimethoxy lariciresinol (4), (+)-(7R,8R)-4-hydroxy-3,3',5'-trimethoxy-8',9'-dinor-8,4'-oxyneoligna-7, 9-diol-7'-aldehyde (5), kaempferol-3-O-(2″,6″-di-O-p-trans-coumaroyl)-β-glucoside (6), arjunolic acid (7), vanillic acid (8), scoparone (9), and β-sitosterol (10). Compounds 2, 6, and 7 showed potent inhibitory effects on nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophages, with IC50 values being 5.62 ± 0.86, 11.47 ± 0.98, and 27.75 ± 1.26 μmol·L(-1), respectively.
