Structure and antibacterial property of a new diterpenoid from Euphorbia helioscopia.
10.1016/S1875-5364(15)30069-8
- Author:
Di GENG
1
;
Li-Tao YI
2
;
Yao SHI
3
;
Zhi-Da MIN
3
Author Information
1. College of Chemical Engineering, Huaqiao University, Xiamen 361021, China. Electronic address: gengyiliang_hqu@163.com.
2. College of Chemical Engineering, Huaqiao University, Xiamen 361021, China.
3. Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
- Publication Type:Journal Article
- Keywords:
Anti-microbial activity;
Euphoheliosnoid E;
Euphorbia helioscopia;
Jatrophone-type diterpenoid
- MeSH:
Anti-Infective Agents;
isolation & purification;
pharmacology;
Diterpenes;
chemistry;
isolation & purification;
pharmacology;
Euphorbia;
chemistry;
Molecular Structure;
Mouth Diseases;
microbiology;
Niacin;
analogs & derivatives;
chemistry;
isolation & purification;
pharmacology;
Plant Extracts;
chemistry;
pharmacology
- From:
Chinese Journal of Natural Medicines (English Ed.)
2015;13(9):704-706
- CountryChina
- Language:English
-
Abstract:
The present study was designed to isolate and evaluate the antibacterial activity of the compounds from the whole plant of Euphorbia helioscopia L.. Various chromatographic techniques were used to isolate and purify the compound. The structure of the compound was elucidated on basis of spectral data ((1)H NMR, (13)C NMR, (1)H-(1)H COSY, HSQC, HMBC, NOESY, IR, and HR-ESI-MS). A new jatrophone-type diterpenoid (14α,15β-diacetoxy-3β-benzoyloxy-7β-nicotinoyloxy-9-oxo-jatropha-5E,11E-diene), named euphoheliosnoid E (1), was isolated from the whole plant of E. helioscopia L. Compound 1 showed significant anti-microbial activity against oral pathogens.
