Current natural products with antihypertensive activity.
10.1016/S1875-5364(15)30072-8
- Author:
Ren-Ren BAI
1
,
2
;
Xiao-Ming WU
3
,
4
;
Jin-Yi XU
3
,
5
Author Information
1. School of Medicine, Emory University, Atlanta 30322, GA, USA
2. Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
3. Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China
4. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. Electronic address: xmwu@cpu.edu.cn.
5. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. Electronic address: jinyixu@china.com.
- Publication Type:Journal Article
- Keywords:
Action mechanism;
Antihypertensive activity;
Lead compounds;
Natural products
- MeSH:
Antihypertensive Agents;
pharmacology;
therapeutic use;
Biological Products;
pharmacology;
therapeutic use;
Humans;
Hypertension;
drug therapy;
Magnoliopsida;
chemistry;
Peptides;
pharmacology;
therapeutic use;
Phytochemicals;
pharmacology;
therapeutic use;
Phytotherapy;
Plant Extracts;
pharmacology;
therapeutic use
- From:
Chinese Journal of Natural Medicines (English Ed.)
2015;13(10):721-729
- CountryChina
- Language:English
-
Abstract:
Natural products have been an important source of new drugs, which also played a dominant role in the discovery and research of new drugs for the treatment of hypertension. This review article reviews the recent progress in the research and development of natural lead compounds with antihypertensive activity, including alkaloids, diterpenes, coumarins, flavonoids, and peptides. We summarized their structures, sources, as well as the antihypertensive mechanisms. These information provides instructive reference for the following structural modifications and optimization.
