Analgesic effects and structural elucidation of two new flavone C-glycosides from Artemisa sacrorum.
10.1016/S1875-5364(15)30080-7
- Author:
Qing-Hu WANG
1
;
Na-Ren-Chao-Ke-Tu HAN
2
;
Na-Yin-Tai DAI
2
;
Rong-Jun WU
2
;
Jie-Si WU
2
Author Information
1. College of Traditional Mongolian Medicine, Inner Mongolia University for Nationalities, Tongliao 028000, China. Electronic address: wqh693@163.com.
2. College of Traditional Mongolian Medicine, Inner Mongolia University for Nationalities, Tongliao 028000, China.
- Publication Type:Journal Article
- Keywords:
Analgesic effect;
Artemisa sacrorum Ledeb;
Sacroroside A;
Sacroroside B
- MeSH:
Analgesics;
chemistry;
isolation & purification;
pharmacology;
therapeutic use;
Animals;
Artemisia;
chemistry;
Disaccharides;
chemistry;
isolation & purification;
pharmacology;
therapeutic use;
Flavanones;
chemistry;
isolation & purification;
pharmacology;
therapeutic use;
Flavones;
chemistry;
isolation & purification;
pharmacology;
therapeutic use;
Hot Temperature;
Male;
Molecular Structure;
Pain;
drug therapy;
Phytotherapy;
Plant Components, Aerial;
Plant Extracts;
chemistry;
pharmacology;
therapeutic use;
Pressure;
Rats, Wistar
- From:
Chinese Journal of Natural Medicines (English Ed.)
2015;13(10):786-790
- CountryChina
- Language:English
-
Abstract:
The present study was designed to isolate and characterize the analgesic compounds of Artemisa sacrorum Ledeb. The EtOAc crude extracts from the aerial parts of Artemisa sacrorum Ledeb were separated by chromatography and the structures of new compounds were elucidated based on spectral analyses. Analgesic activities of the isolated compounds were assessed in rats with hot plate test and paw pressure assay. Two new flavone C-glycosides, named as Sacroroside A and B (Compounds 1 and 2) were isolated from the EtOAc crude extract of the aerial parts ofArtemisa sacrorum Ledeb. They showed significant analgesic effects. In conclusion, Compounds 1 and 2 are new natural products, which show significant analgesic effects in a dose-dependent manner.
