Fumigaclavine I, a new alkaloid isolated from endophyte Aspergillus terreus.
10.1016/S1875-5364(15)30101-1
- Author:
Li SHEN
1
,
2
;
Li ZHU
3
;
Qian LUO
3
;
Xiao-Wen LI
3
;
Ju-Qun XI
1
,
4
;
Gui-Mei KONG
5
;
Yong-Chun SONG
6
Author Information
1. Medical College, Yangzhou University, Yangzhou 225001, China
2. Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China. Electronic address: shenli@yzu.edu.cn.
3. Medical College, Yangzhou University, Yangzhou 225001, China.
4. Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou 225001, China.
5. Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou 225001, China.
6. Institute of Functional Biomolecules, Nanjing University, Nanjing 210046, China.
- Publication Type:Journal Article
- Keywords:
Aspergillus terreus;
Chemical constituent;
Endophyte;
Ergot alkaloid
- MeSH:
Antineoplastic Agents;
chemistry;
isolation & purification;
Aspergillus;
chemistry;
isolation & purification;
Cell Line, Tumor;
Cell Survival;
drug effects;
Endophytes;
chemistry;
isolation & purification;
Ergot Alkaloids;
chemistry;
isolation & purification;
Humans;
Magnetic Resonance Spectroscopy;
Molecular Structure;
Oryza;
microbiology
- From:
Chinese Journal of Natural Medicines (English Ed.)
2015;13(12):937-941
- CountryChina
- Language:English
-
Abstract:
The present study was designed to isolate and purify chemical constituents from solid culture of endophyte Aspergillus terreus LQ, using silica gel column chromatography, gel filtration with Sephadex LH-20, and HPLC. Fumigaclavine I (1), a new alkaloid, was obtained, along with seven known compounds, including fumigaclavine C (2), rhizoctonic acid (3), monomethylsulochrin (4), chaetominine (5), spirotryprostatin A (6), asperfumoid (7), and lumichrome (8). The structure of compound 1 was elucidated by various spectroscopic analyses (UV, MS, 1D and 2D NMR). The in vitro cytotoxicity of compound 1 was determined by MTT assay in human hepatocarcinoma cell line SMMC-7721, showing weaker cytotoxicity, compared with cisplatin, a clinically used cancer chemotherapeutic agent.
