Enhancement of gut permeation of amoxicillin with Nigella sativa seed extract and its phytochemical screening.
10.1016/S1875-5364(18)30038-4
- Author:
Babar ALI
1
,
2
;
Mohammad ALI
3
;
Saima AMIN
3
;
Showkat R MIR
4
Author Information
1. College of Pharmacy and Dentistry, Buraydah Colleges, Buraydah, Al-Qassim, P.O. 31717, Kingdom of Saudi Arabia
2. Phytopharmaceuticals Research Lab, Department of Pharmacognosy and Phytochemistry, School of Pharmaceutical Education and Research (Formerly Faculty of Pharmacy), Jamia Hamdard, PO Hamdard Nagar, New Delhi-110062, India.
3. Phytopharmaceuticals Research Lab, Department of Pharmacognosy and Phytochemistry, School of Pharmaceutical Education and Research (Formerly Faculty of Pharmacy), Jamia Hamdard, PO Hamdard Nagar, New Delhi-110062, India.
4. Phytopharmaceuticals Research Lab, Department of Pharmacognosy and Phytochemistry, School of Pharmaceutical Education and Research (Formerly Faculty of Pharmacy), Jamia Hamdard, PO Hamdard Nagar, New Delhi-110062, India. Electronic address: showkatrmir@gmail.com.
- Publication Type:Journal Article
- Keywords:
Amoxicillin;
Bioavailability;
Everted rat sac;
Homolabdane;
Nigella sativa
- MeSH:
Amoxicillin;
pharmacokinetics;
Animals;
Anti-Bacterial Agents;
pharmacokinetics;
Intestine, Small;
metabolism;
Male;
Molecular Structure;
Nigella sativa;
chemistry;
Phytochemicals;
chemistry;
metabolism;
Plant Extracts;
chemistry;
metabolism;
Rats;
Rats, Wistar;
Seeds;
chemistry
- From:
Chinese Journal of Natural Medicines (English Ed.)
2018;16(2):125-130
- CountryChina
- Language:English
-
Abstract:
The seeds of Nigella sativa Linn. (Ranunculaceae), commonly known as Black cumin, are predominantly used as carminative, antispasmodic, and stimulant. The main objective of the present study was to evaluate the effect of N. sativa seed extract on the permeation of co-infused amoxicillin across the gut wall. The methanolic extract of N. sativa improved intestinal permeability of amoxicillin in in-vitro experiments in a dose-dependent manner. Two new glycosides, decanyl nigelloic acid diglucoside [n-decanyl-3-aldehydic-4-methoxy-5-hydroxy benzoate-5-β-D-glucofuranosyl (2→1)-β-D-glucopyranosyl-(2→1)-β-D-glucopyranoside]] and nigelabdienoyl triglucoside [homo-labd-5, 9(11)-dien-16-onyl-β-D-glucopyranosyl (2→1)-β-D-glucopyranosyl (2→1)-β-D-glucopyranoside], along with seven known fatty acid glycerides/esters, were isolated from the gut permeation enhancing extract. The structures of these new glycosides were elucidated by detailed spectroscopic analyses.
