Three new alkaloids isolated from the stem tuber of Pinellia pedatisecta.
10.1016/S1875-5364(18)30040-2
- Author:
Jing DU
1
;
Jie DING
1
;
Zhen-Qiang MU
1
;
Shu-Hong GUAN
2
;
Chun-Ru CHENG
3
;
Xuan LIU
4
;
De-An GUO
2
Author Information
1. School of Chemical Engineering, Institute of Pharmaceutical Engineering Technology and Application, Key Laboratory of Green Chemistry of Sichuan Institutes of Higher Education, Sichuan University of Science & Engineering, Zigong 643000, China.
2. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
3. School of Chemical Engineering, Institute of Pharmaceutical Engineering Technology and Application, Key Laboratory of Green Chemistry of Sichuan Institutes of Higher Education, Sichuan University of Science & Engineering, Zigong 643000, China. Electronic address: pharmaceutics@163.com.
4. Institute of Interdisciplinary Integrative Biomedical Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address: 13764960370@163.com.
- Publication Type:Journal Article
- Keywords:
Alkaloids;
Anti-tumor;
Pinellia pedatisecta;
Structure identification
- MeSH:
Alkaloids;
chemistry;
isolation & purification;
pharmacology;
Cell Proliferation;
drug effects;
HeLa Cells;
Humans;
Pinellia;
chemistry;
Plant Extracts;
chemistry;
isolation & purification;
pharmacology;
Plant Stems;
chemistry;
Plant Tubers;
chemistry
- From:
Chinese Journal of Natural Medicines (English Ed.)
2018;16(2):139-142
- CountryChina
- Language:English
-
Abstract:
The present study was designed to determine the chemical constituents of the stem tuber of Pinellia pedatisecta. The chemical constituents were isolated and purified by various chromatographic techniques, and their structures were elucidated on the basis of physicochemical properties and spectral data. Three new alkaloids (compounds 1, 2, and 3) were obtained and identified as 9-((5-methoxypyridin-2-yl)methyl)-9H-purin-6-amine (1), 4-(2-(2, 5-dioxopyrrolidin-1-yl)ethyl)phenyl acetate (2), and N-(9-((5-methoxypyridin-2-yl)methyl)-9H-purin-6-yl)acetamide (3). These compounds were evaluated for their cytotoxicity against human cervical cancer HeLa cells. Compounds 1 and 3 significantly inhibited the proliferation of HeLa cells with IC values being 3.02 ± 0.54 and 7.16 ± 0.62 μmol·L, respectively.
