Bamboo salt suppresses skin inflammation in mice with 2, 4-dinitrofluorobenzene-induced atopic dermatitis.
10.1016/S1875-5364(18)30035-9
- Author:
Myoung-Schook YOOU
1
;
Sun-Young NAM
1
;
Kyoung WAN YOON
2
;
Hyun-Ja JEONG
3
;
Hyung-Min KIM
4
Author Information
1. Department of Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.
2. Department of Biotechnology, Hoseo University, Chungcheongnam-do 31499, Republic of Korea.
3. Department of Food Science & Technology and Research Institute for Basic Science, Hoseo University, Chungcheongnam-do 31499, Republic of Korea. Electronic address: hjjeong@hoseo.edu.
4. Department of Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea. Electronic address: hmkim@khu.ac.kr.
- Publication Type:Journal Article
- Keywords:
Atopic dermatitis;
Bamboo salt;
Caspase-1;
Thymic stromal lymphopoietin
- MeSH:
Animals;
Caspase 1;
genetics;
immunology;
Dermatitis, Atopic;
chemically induced;
drug therapy;
genetics;
immunology;
Dinitrofluorobenzene;
adverse effects;
Disease Models, Animal;
Female;
Histamine;
immunology;
Humans;
Immunoglobulin E;
immunology;
Interleukin-13;
genetics;
immunology;
Interleukin-5;
genetics;
immunology;
Mice;
Mice, Inbred BALB C;
Sodium Chloride, Dietary;
administration & dosage
- From:
Chinese Journal of Natural Medicines (English Ed.)
2018;16(2):97-104
- CountryChina
- Language:English
-
Abstract:
Bamboo salt (BS) is a traditional Korean food, and has been reported to have anti-cancer, anti-inflammatory, and anti-metastatic effects. However, the anti-atopic dermatitis (AD) activity of BS has not been described yet. In the present study, we examined the preventive effect of BS on AD. The effect of oral administration of BS was tested in a 2, 4-dinitrofluorobenzene (DNFB)-induced AD animal model, by histological analysis, enzyme-linked immunosorbent assay, reverse transcription-polymerase chain reaction, caspase-1 assay, and Western blotting analysis. BS administration reduced the total clinical severity and scratching frequencies, compared with the AD group. In the serum of DNFB-induced AD mice, the levels of IgE, histamine, thymic stromal lymphopoietin (TSLP), interleukin (IL)-5, and IL-13 were significantly reduced by BS treatment. BS significantly reduced the protein and mRNA expression of TSLP, IL-6, and tumor necrosis factor-α in the AD skin lesions. BS markedly reduced the infiltration of inflammatory cells. Furthermore, the activation of caspase-1 was reduced by BS in the AD skin lesions. Our results suggested that BS should be considered as a candidate treatment for allergic inflammatory diseases including AD.
