Sedative and antinociceptive activities of two new sesquiterpenes isolated from Ricinus communis.
10.1016/S1875-5364(18)30051-7
- Author:
Umar FAROOQ
1
;
Ajmal KHAN
2
,
3
;
Sadia NAZ
4
;
Abdur RAUF
5
;
Haroon KHAN
6
;
Afsar KHAN
7
;
Irfan ULLAH
8
;
Syed Majid BUKHARI
4
Author Information
1. Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan. Electronic address: umarf@ciit.net.pk.
2. Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan
3. UoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Nizwa 616, Sultanate of Oman. Electronic address: ajmalkhan@ciit.net.pk.
4. Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan.
5. Department of Geology, University of Swabi Anbar, Khyber Pakhtunkhwa 23430, Pakistan.
6. Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan.
7. Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan. Electronic address: afsarkhan@ciit.net.pk.
8. Department of Pharmacy, Abasyn University, Peshawar 25000, Pakistan.
- Publication Type:Journal Article
- Keywords:
Antinociceptive activity;
Euphorbiaceae;
Ricinus communis;
Sesquiterpenoids;
Spectroscopic techniques
- MeSH:
Analgesics;
administration & dosage;
chemistry;
isolation & purification;
Animals;
Humans;
Hypnotics and Sedatives;
administration & dosage;
chemistry;
isolation & purification;
Locomotion;
drug effects;
Male;
Mice;
Mice, Inbred BALB C;
Molecular Structure;
Pain;
drug therapy;
physiopathology;
Plant Extracts;
administration & dosage;
chemistry;
isolation & purification;
Plant Leaves;
chemistry;
Ricinus;
chemistry;
Sesquiterpenes;
administration & dosage;
chemistry;
isolation & purification
- From:
Chinese Journal of Natural Medicines (English Ed.)
2018;16(3):225-230
- CountryChina
- Language:English
-
Abstract:
Two new sesquiterpenes, trivially named ricinusoids A (1) and ricinusoids B (2), were isolated from ethyl acetate fraction of Ricinus communis. The structures of new compounds were elucidated by detailed spectroscopic techniques, including 1D- and 2D-NMR, UV, IR spectroscopy, and mass spectrometry. The compounds (1-2) were also assessed for in-vivo sedative and analgesic like effects in open field and acetic acid induced writhing tests respectively at 5, 10, and 20 mg·kg i.p. Pretreatment of both test compounds caused significant (P ≤ 0.05) reduction in locomotive activity like sedative agents and abdominal constrictions like analgesics. Both compounds (1-2) possessed marked sedative and antinociceptive effects in animal models.
