Chemical constituents from Gnaphalium affine and their xanthine oxidase inhibitory activity.
10.1016/S1875-5364(18)30066-9
- Author:
Wei ZHANG
1
,
2
;
Chun-Zhen WU
1
,
3
;
Si-Yang FAN
1
,
4
Author Information
1. Department of Traditional Chinese Medicine, Shanghai Institute of Pharmaceutical Industry, Shanghai 201203, China
2. Innovation Center of Traditional Chinese Medicine, China State Institute of Pharmaceutical Industry, Shanghai 201203, China.
3. Sinopharm Health Industry Research Co., Ltd., Shanghai 201203, China.
4. Innovation Center of Traditional Chinese Medicine, China State Institute of Pharmaceutical Industry, Shanghai 201203, China. Electronic address: max_121@163.com.
- Publication Type:Journal Article
- Keywords:
Caffeoylquinate;
Compositae;
Flavonoid;
Gnaphalium affine;
Xanthine oxidase inhibition
- MeSH:
Adenine;
analogs & derivatives;
chemistry;
isolation & purification;
Drugs, Chinese Herbal;
chemistry;
pharmacology;
Enzyme Activation;
drug effects;
Flavonoids;
chemistry;
isolation & purification;
Gnaphalium;
chemistry;
Gout Suppressants;
chemistry;
isolation & purification;
pharmacology;
Hydroxybenzoates;
chemistry;
isolation & purification;
Molecular Structure;
Nuclear Magnetic Resonance, Biomolecular;
Phytochemicals;
chemistry;
isolation & purification;
pharmacology;
Plant Components, Aerial;
chemistry;
Plant Extracts;
chemistry;
isolation & purification;
pharmacology;
Quinic Acid;
analogs & derivatives;
chemistry;
isolation & purification;
Xanthine Oxidase;
antagonists & inhibitors
- From:
Chinese Journal of Natural Medicines (English Ed.)
2018;16(5):347-353
- CountryChina
- Language:English
-
Abstract:
Gnaphalium affine D. Don, a medicinal and edible plant, has been used to treat gout in traditional Chinese medicine and popularly consumed in China for a long time. A detailed phytochemical investigation on the aerial part of G. affine led to the isolation of two new esters of caffeoylquinic acid named (-) ethyl 1, 4-di-O-caffeoylquinate (1) and (-) methyl 1, 4-di-O-caffeoylquinate (2), together with 35 known compounds (3-37). Their structures were elucidated by spectroscopic data and first-order multiplet analysis. All the isolated compounds were tested for their xanthine oxidase inhibitory activity with an in vitro enzyme inhibitory screening assay. Among the tested compounds, 1 (IC 11.94 μmol·L) and 2 (IC 15.04 μmol·L) showed a good inhibitory activity. The current results supported the medical use of the plant.
