Mori Cortex extract ameliorates nonalcoholic fatty liver disease (NAFLD) and insulin resistance in high-fat-diet/streptozotocin-induced type 2 diabetes in rats.
10.1016/S1875-5364(18)30074-8
- Author:
Li-Li MA
1
;
Yan-Yan YUAN
1
;
Ming ZHAO
1
;
Xin-Rong ZHOU
1
;
Tashina JEHANGIR
1
;
Fu-Yan WANG
1
;
Yang XI
1
;
Shi-Zhong BU
2
Author Information
1. Runliang Diabetes Laboratory, Diabetes Research Center, School of Medicine, Ningbo University, Ningbo 315000, China.
2. Runliang Diabetes Laboratory, Diabetes Research Center, School of Medicine, Ningbo University, Ningbo 315000, China. Electronic address: shizhongbu@nbu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Carbohydrate-responsive element binding protein;
Mori Cortex extract;
Non-alcoholic fatty liver;
Sterol receptor element-binding protein-1c;
Type 2 diabetes
- MeSH:
Alanine Transaminase;
blood;
Animals;
Aspartate Aminotransferases;
blood;
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors;
genetics;
Diabetes Mellitus, Type 2;
blood;
chemically induced;
drug therapy;
metabolism;
Diet, High-Fat;
adverse effects;
Disease Models, Animal;
Down-Regulation;
drug effects;
Insulin;
blood;
Insulin Resistance;
physiology;
Lipid Metabolism;
drug effects;
genetics;
Liver;
drug effects;
physiopathology;
Male;
Morus;
Non-alcoholic Fatty Liver Disease;
blood;
chemically induced;
drug therapy;
metabolism;
Phytotherapy;
Plant Extracts;
pharmacology;
therapeutic use;
Rats;
Rats, Sprague-Dawley;
Streptozocin
- From:
Chinese Journal of Natural Medicines (English Ed.)
2018;16(6):411-417
- CountryChina
- Language:English
-
Abstract:
Nonalcoholic fatty liver disease (NAFLD) and type 2 Diabetes Mellitus (T2DM) are highly prevalent diseases and are closely associated, with NAFLD being present in the majority of T2DM patients. In Asian traditional medicine, Mori Cortex is widely used for the treatment of diabetes and hyperlipidemia. However, whether it has a therapeutic effect on T2DM associated with NAFLD is still unknown. The present study showed that the oral treatment with Mori Cortex extract (MCE; 10 g·kg·d) lowered the blood lipid levels and reversed insulin resistance (IR) in high fat-diet/streptozotocin-induced type 2 diabetes in rats. The expression levels of sterol receptor element-binding protein-1c (SREBP-1c) and carbohydrate-responsive element binding protein (ChREBP), which are involved in steatosis in NAFLD rats, were measured in the liver samples. MCE decreased the protein and mRNA expression levels of SREBP-1c and ChREBP. In conclusion, down-regulation of SREBP-1c and ChREBP might contribute to the protective effect of MCE on hepatic injury and IR in the rats with T2DM associated with NAFLD.
