Scopariusols L-T, nine new ent-kaurane diterpenoids isolated from Isodon scoparius.
10.1016/S1875-5364(18)30079-7
- Author:
Hua-Yi JIANG
1
,
2
,
3
;
Xiao-Nian LI
4
;
Han-Dong SUN
4
;
Hong-Bin ZHANG
5
;
Pema-Tenzin PUNO
6
Author Information
1. Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China
2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
3. University of Chinese Academy of Sciences, Beijing 100049, China.
4. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
5. Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China. Electronic address: zhanghb@ynu.edu.cn.
6. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. Electronic address: punopematenzin@mail.kib.ac.cn.
- Publication Type:Journal Article
- Keywords:
Anti-inflammatory activity;
Cytotoxicity;
Ent-kaurane diterpenoids;
Isodon scoparius;
X-ray diffraction
- MeSH:
Animals;
Antineoplastic Agents, Phytogenic;
chemistry;
isolation & purification;
pharmacology;
Cell Line, Tumor;
Crystallography, X-Ray;
Diterpenes, Kaurane;
chemistry;
isolation & purification;
pharmacology;
Drug Screening Assays, Antitumor;
Drugs, Chinese Herbal;
chemistry;
isolation & purification;
pharmacology;
HL-60 Cells;
Humans;
Isodon;
chemistry;
Lipopolysaccharides;
pharmacology;
Macrophages;
drug effects;
Mice;
Molecular Structure;
Nitric Oxide;
biosynthesis;
Nuclear Magnetic Resonance, Biomolecular;
Plant Components, Aerial;
chemistry;
RAW 264.7 Cells
- From:
Chinese Journal of Natural Medicines (English Ed.)
2018;16(6):456-464
- CountryChina
- Language:English
-
Abstract:
Nine new ent-kaurane diterpenoids, named scopariusols L-T (1-9), were isolated from the aerial parts of Isodon scoparius. Their structures were characterized mainly by analyzing the NMR and HR-ESI-MS data, and the absolute configuration of 1 was determined by single-crystal X-ray diffraction. Compound 1 was active against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW-480), and it also inhibited NO production in LPS-stimulated RAW264.7 cells, with an IC value of 0.6 μmol·L.
