New steroidal alkaloid and furostanol glycosides isolated from Solanum lyratum with cytotoxicity.
10.1016/S1875-5364(18)30085-2
- Author:
Yun-Ling XU
1
;
Jia LV
2
,
3
;
Wei-Fang WANG
2
,
3
;
Yue LIU
4
;
Ya-Juan XU
2
,
5
;
Tun-Hai XU
6
Author Information
1. School of Chinese Pharmacy, Beijing University of Traditional Chinese Medicine, Beijing 100029, China.
2. Key Laboratory of Effective Substances of Traditional Chinese Medicine, Jilin Academy of Chinese Medicine Sciences, Changchun 130012, China
3. School of Traditional Chinese Medicine, Changchun University of Traditional Chinese Medicine, Changchun 130031, China.
4. Key Laboratory of Effective Substances of Traditional Chinese Medicine, Jilin Academy of Chinese Medicine Sciences, Changchun 130012, China.
5. School of Traditional Chinese Medicine, Changchun University of Traditional Chinese Medicine, Changchun 130031, China. Electronic address: xyj6492@126.com.
6. School of Chinese Pharmacy, Beijing University of Traditional Chinese Medicine, Beijing 100029, China. Electronic address: thxu@163.com.
- Publication Type:Journal Article
- Keywords:
Cytotoxic activity;
Furostanol glycoside;
Solanum lyratum;
Steroidal alkaloid
- MeSH:
Alkaloids;
chemistry;
isolation & purification;
toxicity;
Antineoplastic Agents;
chemistry;
isolation & purification;
toxicity;
Cell Line, Tumor;
Cell Survival;
drug effects;
Glycosides;
chemistry;
pharmacology;
toxicity;
Humans;
Inhibitory Concentration 50;
Molecular Structure;
Phytosterols;
chemistry;
isolation & purification;
toxicity;
Plant Extracts;
chemistry;
toxicity;
Plants, Medicinal;
chemistry;
Solanum;
chemistry;
Sterols;
chemistry;
pharmacology;
toxicity
- From:
Chinese Journal of Natural Medicines (English Ed.)
2018;16(7):499-504
- CountryChina
- Language:English
-
Abstract:
Two previously undescribed steroidal compounds, 16, 23-epoxy-22, 26-epimino-cholest-22(N), 23, 25(26)-trien-3β-ol-3-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside (1) and 26-O-β-D-glucopyranosyl-(25R)-5α-furost-20(22)-en-3β, 26-diol (2), together with 7 known ones including 26-O-β-D-glucopyranosyl-(25R)-5, 20(22)-dien-furost-3β, 26-diol (3), (25R)-5-en-spirost-3β-ol-O-β-D-glucopyranosyl-(1→4)-[α-L-rhmanopyranosyl-(1→2)]-β-D-galactopyranoside (4), funkioside D (5), aspidistrin (6), tigogenin-3-O-β-D-lucotrioside (7), desglucolanatigonin II (8), and degalactotigonin (9), were isolated from Solanum lyratum Thunb. Their cytotoxic activities were tested in two cancer cell lines by MTT method. One of the steroidal glycosides (6) showed significant cytotoxic activity against gastric cancer SGC7901 and liver cancer BEL-7402 cells.
