Carbazole alkaloids isolated from the branch and leaf extracts of Clausena lansium.
10.1016/S1875-5364(18)30087-6
- Author:
Wen-Wen PENG
1
,
2
;
Li-Xia ZHENG
3
;
Chang-Jiu JI
4
;
Xu-Gen SHI
3
;
Zhong-Hua XIONG
3
;
Xin-Chen SHANGGUAN
5
Author Information
1. College of Agriculture, Jiangxi Agricultural University, Nanchang 330045, China
2. Jiangxi Key Laboratory of Natural Products and Functional Food, Jiangxi Agricultural University, Nanchang 330045, China. Electronic address: peng-wenwen123@sina.com.
3. College of Agriculture, Jiangxi Agricultural University, Nanchang 330045, China.
4. Jiangxi Yichun University, Yichun 336000, China.
5. Jiangxi Key Laboratory of Natural Products and Functional Food, Jiangxi Agricultural University, Nanchang 330045, China.
- Publication Type:Journal Article
- Keywords:
Carbazole alkaloids;
Clausena lansium;
Cytotoxic activity
- MeSH:
A549 Cells;
Alkaloids;
chemistry;
isolation & purification;
toxicity;
Antineoplastic Agents;
chemistry;
isolation & purification;
toxicity;
Carbazoles;
chemistry;
isolation & purification;
toxicity;
Cell Line, Tumor;
Cell Survival;
drug effects;
Clausena;
chemistry;
HeLa Cells;
Humans;
Molecular Structure;
Plant Extracts;
chemistry;
toxicity;
Plant Leaves;
chemistry;
Plant Stems;
chemistry;
Plants, Medicinal;
chemistry
- From:
Chinese Journal of Natural Medicines (English Ed.)
2018;16(7):509-512
- CountryChina
- Language:English
-
Abstract:
The present study carried out a phytochemical investigation of the methanol extract of the branches and leaves of Clausena lansium and afforded nine carbazole alkaloids (compounds 1-9) including two new carbazole alkaloids, claulansiums A and B (compounds 1 and 2). The new compounds were elucidated on the basis of extensive spectroscopic data (MS, NMR, IR, and UV) and the known compounds were identified by comparing spectroscopic data with those reported in literature. All the isolated compounds were tested for their cytotoxic activity against A549 and Hela cancer cell lines. Our results showed that compounds 2-6 exhibited varying degrees of cytotoxicity to cancer cells, with IC values ranging from 8.67 to 98.89 μmol·L.
