Application of alkaloids in reversing multidrug resistance in human cancers.
10.1016/S1875-5364(18)30093-1
- Author:
Meng WANG
1
;
Ze-Fa LIU
2
;
Hua TANG
2
;
Bao-An CHEN
3
Author Information
1. Department of Hematology and Oncology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.
2. Department of Hematology, People's Hospital of Xinghua City, Xinghua 225700, China.
3. Department of Hematology and Oncology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China. Electronic address: cba8888@hotmail.com.
- Publication Type:Journal Article
- Keywords:
Alkaloids;
Cancer;
Multidrug resistance
- MeSH:
Alkaloids;
administration & dosage;
chemistry;
Animals;
Biological Products;
administration & dosage;
chemistry;
Drug Antagonism;
Drug Resistance, Multiple;
Drug Resistance, Neoplasm;
Humans;
Neoplasms;
drug therapy
- From:
Chinese Journal of Natural Medicines (English Ed.)
2018;16(8):561-571
- CountryChina
- Language:English
-
Abstract:
Multidrug resistance (MDR) in human cancer is one of greatest challenges in cancer therapy. Natural products, especially the alkaloids, exert reversed effects on MDR with low toxicity, by interacting with various targets. In this review article, we summarize the recent progress made in the research of the main alkaloids, including classification, function, mechanism, research status, and application in reversing MDR.
