Two new C steroidal glycosides isolated from Cynanchum komarovii.
10.1016/S1875-5364(18)30098-0
- Author:
Dan ZHAO
1
,
2
;
Shan-Shan SU
3
;
Shao-Fei CHEN
1
,
2
;
Xiao-Jie LU
1
,
2
;
Gang CHEN
1
,
2
;
Yu-Bo WANG
1
,
4
,
5
;
Guang-Yue SU
1
,
6
;
Yue-Hu PEI
1
,
7
Author Information
1. Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China
2. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
3. Testing Laboratory, Qinghai Entry Exit Inspection and Quarantine Bureau, Xining 810000, China.
4. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
5. School of Pharmacy, Jinzhou Medical University, Jinzhou 121001, China.
6. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: suggyy@163.com.
7. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: peiyueh@vip.163.com.
- Publication Type:Journal Article
- Keywords:
C(21) steroidal glycosides;
Cynanchum komarovii;
Cytotoxic activity
- MeSH:
Cell Survival;
drug effects;
Cynanchum;
chemistry;
Drugs, Chinese Herbal;
chemistry;
isolation & purification;
pharmacology;
Glycosides;
chemistry;
isolation & purification;
pharmacology;
HL-60 Cells;
Humans;
Magnetic Resonance Spectroscopy;
Molecular Structure;
Steroids;
chemistry;
isolation & purification;
pharmacology
- From:
Chinese Journal of Natural Medicines (English Ed.)
2018;16(8):610-614
- CountryChina
- Language:English
-
Abstract:
The present study was designed to further investigate the C steroidal glycosides in Cynanchum plants. Two new steroidal glycosides based on a 13, 14:14, 15-disecopregnane-type aglycone, komaroside P (1) and komaroside Q (2), together with three known compounds (3-5) were isolated from the whole herbs of Cynanchum komarovii. The aglycones of compounds 1 and 2 were two new disecopregnane. Their structures were elucidated on the basis of 1D, 2D NMR spectroscopic data and acid hydrolysis. All the compounds (1-5) showed potent inhibitory activities against human leukemia cell lines (HL-60) with IC values ranging from 16.6 to 26.3 μmol·L, compared to the positive control 5-fluorouracil (6.4 μmol·L).
