New flavonoids and methylchromone isolated from the aerial parts of Baeckea frutescens and their inhibitory activities against cyclooxygenases-1 and -2.
10.1016/S1875-5364(18)30099-2
- Author:
Jun-Neng ZHOU
1
;
Ming YAN
2
;
Peng GAO
2
;
Ji-Qin HOU
1
;
Thi-Anh PHAM
1
;
Hao WANG
3
Author Information
1. State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
2. Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China.
3. State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China. Electronic address: wanghao@cpu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Baeckea frutescens;
Cyclooxygenase-1;
Cyclooxygenase-2;
Flavonoid;
Methylchromone
- MeSH:
Anti-Inflammatory Agents;
chemistry;
isolation & purification;
Cyclooxygenase 1;
chemistry;
Cyclooxygenase 2;
chemistry;
Cyclooxygenase Inhibitors;
chemistry;
isolation & purification;
Flavonoids;
chemistry;
isolation & purification;
Molecular Structure;
Myrtaceae;
chemistry;
Plant Components, Aerial;
chemistry;
Plant Extracts;
chemistry;
isolation & purification
- From:
Chinese Journal of Natural Medicines (English Ed.)
2018;16(8):615-620
- CountryChina
- Language:English
-
Abstract:
In the present study, we carried out a phytochemical investigation of the ethanol extract of the aerial parts of Baeckea frutescens, which resulted in the isolation of two new flavonoid glycosides, myricetin 3-O-(5″-O-galloyl)-α-L-arabinofuranoside (1), 6-methylquercetin 7-O-β-D-glucopyranoside (2), one new methylchromone glycoside, 7-O-(4', 6'-digalloyl)-β-D-glucopyranosyl-5-hydroxy-2-methylchromone (3), together with three known compounds (4-6). The structures of these isolated compounds were established on the basis of 1D and 2D NMR techniques and chemical methods. The anti-inflammatory activities of the compounds 1-6 were evaluated for their inhibitory effects against cyclooxygenases-1 and -2 in vitro. Compounds 1-6 showed potent COX-1 and COX-2 inhibiting activities in vitro with IC values ranging from 1.95 to 5.54 μmol·L and ranging from 1.01 to 2.27 μmol·L, respectively.
