Novel sesquiterpenoids isolated from Chimonanthus praecox and their antibacterial activities.
10.1016/S1875-5364(18)30100-6
- Author:
Hua-Yong LOU
1
,
2
,
3
;
Yu ZHANG
1
,
3
;
Xiao-Pan MA
4
;
Sai JIANG
4
;
Xiang-Pei WANG
5
;
Ping YI
3
,
6
;
Guang-Yi LIANG
1
,
2
,
3
;
Hong-Mei WU
5
;
Jing FENG
5
;
Feng-Yun JIN
7
;
Wei-Dong PAN
6
,
8
Author Information
1. Guiyang College of Traditional Chinese Medicine, Guiyang 550002, China
2. State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China
3. The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China.
4. The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China.
5. Guiyang College of Traditional Chinese Medicine, Guiyang 550002, China.
6. State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China
7. Guiyang College of Traditional Chinese Medicine, Guiyang 550002, China. Electronic address: jinfengyun01@163.com.
8. The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China. Electronic address: wdpan@163.com.
- Publication Type:Journal Article
- Keywords:
Antimicrobial activities;
Chimonanthus praecox;
Electronic circular dichroism;
Sesquiterpenoids
- MeSH:
Anti-Bacterial Agents;
chemistry;
isolation & purification;
pharmacology;
Calycanthaceae;
chemistry;
Escherichia coli;
drug effects;
Microbial Sensitivity Tests;
Molecular Structure;
Plant Extracts;
chemistry;
isolation & purification;
pharmacology;
Sesquiterpenes;
chemistry;
isolation & purification;
pharmacology;
Staphylococcus aureus;
drug effects
- From:
Chinese Journal of Natural Medicines (English Ed.)
2018;16(8):621-627
- CountryChina
- Language:English
-
Abstract:
In the present study, four new sesquiterpenoids, chimonols A-D (compounds 1-4), together with four known compounds (5-8) were isolated from the EtOAc extract of Chimonanthus praecox Link. The structures of these new compounds were elucidated on the basis of spectroscopic techniques (UV, IR, MS, and 1D and 2D NMR), and their absolute configurations were established by comparing experimental and calculated electronic circular dichroism (ECD) spectra. Compounds 1-8 were evaluated for antimicrobial activities and the minimum inhibitory concentrations (MICs) were determined by the broth microdilution method in 96-well culture plates. Compounds 1, 2, and 7 exhibited weak antibacterial effects for S. aureus (ATCC 6538), E. coli (ATCC 11775), and P. aeruginosa (ATCC 10145) with MIC values being 158-249 µg·mL. Compounds 3-7 showed activities against C. glabrata (ATCC 2001) and S. aureus (ATCC 43300) with MIC values being 128-197 µg·mL. Compounds 1-4 showed activity against S. aureus (ATCC 25923) with MIC values being 162-254 µg·mL. The present study provided a basis for future evaluation of these compounds as antibacterial agents.
