Stems and leaves of Aconitum carmichaelii Debx. as potential herbal resources for treating rheumatoid arthritis: Chemical analysis, toxicity and activity evaluation.
10.1016/S1875-5364(18)30104-3
- Author:
Ya-Nan HE
1
;
Shui-Ping OU
2
,
3
;
Xi XIONG
1
;
Yuan PAN
1
;
Jin PEI
2
,
4
;
Run-Chun XU
1
;
Fu-Neng GENG
5
;
Li HAN
1
;
Ding-Kun ZHANG
2
,
6
;
Ming YANG
7
Author Information
1. State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
2. State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
3. Affiliated Hospital of Zunyi Medical College, Zunyi 563000, China.
4. Sichuan Good Doctor Panxi Pharmaceutical Co., Ltd., Xichang 615000, China.
5. Sichuan Good Doctor Panxi Pharmaceutical Co., Ltd., Xichang 615000, China.
6. Sichuan Good Doctor Panxi Pharmaceutical Co., Ltd., Xichang 615000, China. Electronic address: 465790643@qq.com.
7. Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. Electronic address: yangming16@126.com.
- Publication Type:Journal Article
- Keywords:
Aconitum carmichaelii Debx.;
Alkaloids;
Efficacy;
New medical parts;
Toxicity
- MeSH:
Aconitum;
chemistry;
Alkaloids;
administration & dosage;
chemistry;
toxicity;
Animals;
Anti-Inflammatory Agents;
administration & dosage;
chemistry;
toxicity;
Arthritis, Rheumatoid;
drug therapy;
Chromatography, High Pressure Liquid;
Drug Evaluation, Preclinical;
Drugs, Chinese Herbal;
administration & dosage;
chemistry;
toxicity;
Female;
Humans;
Male;
Mice;
Plant Leaves;
chemistry;
Plant Roots;
chemistry;
Plant Stems;
chemistry;
Tandem Mass Spectrometry
- From:
Chinese Journal of Natural Medicines (English Ed.)
2018;16(9):644-652
- CountryChina
- Language:English
-
Abstract:
According to folk usage of Aconitum carmichaelii Debx., the present study was designed to determine the feasibility of the stems and leaves of Aconitum carmichaelii Debx. as a new medicinal resource. Fourteen alkaloids in mother roots, fibrous roots, stems, and leaves of Aconitum carmichaelii Debx. were measured by HPLC-MS/MS. And multivariate analysis methods, such as clustering analysis and principal component analysis, were applied to analyze the difference among various parts. In addition, the acute toxicity, analgesia, and anti-inflammatory tests were carried out. The results suggested that the contents of alkaloids in mother roots and fibrous roots were approximate, but those of leaves and stems were different from mother roots and fibrous roots. The results of the acute toxicity testing demonstrated the toxicity of fibrous root was strongest, and mother roots were slightly less toxic than fibrous roots. The stems and leaves were far less toxic than mother and fibrous roots. In addition, the analgesia and inflammatory tests showed the effects of the various tissues had no difference each other. These results provided a basis for developing new complementary and alternative treatments for rheumatoid arthritis patients. Simultaneously, the approach may also turn wastes into treasure and promote the development of circular economy.
