Sodium tanshinone IIA sulfonate attenuates cardiac dysfunction and improves survival of rats with cecal ligation and puncture-induced sepsis.
10.1016/S1875-5364(18)30126-2
- Author:
Zheng-Jie MENG
1
,
2
;
Chao WANG
3
;
Ling-Tong MENG
4
;
Bei-Hua BAO
5
;
Jin-Hui WU
6
;
Yi-Qiao HU
7
Author Information
1. College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China
2. State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing 210093, China.
3. School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China.
4. State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing 210093, China.
5. Jiangsu Key Laboratory for High Technology of Traditional Chinese Medicine Formulae Research, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
6. State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing 210093, China. Electronic address: wuj@nju.edu.cn.
7. State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing 210093, China. Electronic address: huyiqiao@nju.edu.cn.
- Publication Type:Journal Article
- Keywords:
Cardiac dysfunction;
Cecal ligation and puncture model;
Cytokine;
Sepsis;
Sodium tanshinone II A sulfonate
- MeSH:
Animals;
C-Reactive Protein;
genetics;
immunology;
Cecum;
surgery;
Drugs, Chinese Herbal;
administration & dosage;
chemistry;
Female;
Heart;
drug effects;
physiopathology;
Humans;
Interleukin-6;
genetics;
immunology;
Ligation;
adverse effects;
Male;
Myocardium;
immunology;
Phenanthrenes;
administration & dosage;
chemistry;
Punctures;
adverse effects;
Rats;
Salvia miltiorrhiza;
chemistry;
Sepsis;
drug therapy;
etiology;
immunology;
physiopathology;
Troponin T;
genetics;
immunology;
Tumor Necrosis Factor-alpha;
genetics;
immunology
- From:
Chinese Journal of Natural Medicines (English Ed.)
2018;16(11):846-855
- CountryChina
- Language:English
-
Abstract:
Cardiac dysfunction, a common consequence of sepsis, is the major contribution to morbidity and mortality in patients. Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of Tanshinone IIA (TA), a main active component of Salvia miltiorrhiza Bunge, which has been widely used in China for the treatment of cardiovascular and cerebral system diseases. In the present study, the effect of STS on sepsis-induced cardiac dysfunction was investigated and its effect on survival rate of rats with sepsis was also evaluated. STS treatment could significantly decrease the serum levels of C-reactive protein (CRP), procalcitonin (PCT), cardiac troponin I (cTn-I), cardiac troponin T (cTn-T), and brain natriuretic peptide (BNP) in cecal ligation and puncture (CLP)-induced) septic rats and improve left ventricular function, particularly at 48 and 72 h after CLP. As the pathogenesis of septic myocardial dysfunction is attributable to dysregulated systemic inflammatory responses, several key cytokines, including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-10 (IL-10) and high mobility group protein B1 (HMGB1), were detected to reveal the possible mechanism of attenuation of septic myocardial dysfunction after being treated by STS. Our study showed that STS, especially at a high dose (15 mg·kg), could efficiently suppress inflammatory responses in myocardium and reduce myocardial necrosis through markedly reducing production of myocardial TNF-α, IL-6 and HMGB1. STS significantly improved the 18-day survival rate of rats with sepsis from 0% to 30% (P < 0.05). Therefore, STS could suppress inflammatory responses and improve left ventricular function in rats with sepsis, suggesting that it may be developed for the treatment of sepsis.
