New limonoids isolated from the bark of Melia toosendan.
10.1016/S1875-5364(18)30136-5
- Author:
Qiong ZHANG
1
;
Qing-Hong ZHENG
2
;
Yi-Shu SANG
3
;
Herman Ho-Yung SUNG
4
;
Zhi-Da MIN
3
Author Information
1. Department of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China. Electronic address: zhangqiong_83@hotmail.com.
2. Department of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China.
3. Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
4. Department of Chemistry, Hong Kong University of Science and Technology, Hongkong, China.
- Publication Type:Journal Article
- Keywords:
Absolute configuration;
Limonoid;
Melia toosendan;
Meliaceae;
Toosendanin
- MeSH:
Cell Line, Tumor;
Cell Proliferation;
drug effects;
Humans;
Limonins;
isolation & purification;
Melia;
chemistry;
Molecular Structure;
Plant Bark;
chemistry;
Plant Extracts;
chemistry;
isolation & purification;
pharmacology;
X-Ray Diffraction
- From:
Chinese Journal of Natural Medicines (English Ed.)
2018;16(12):946-950
- CountryChina
- Language:English
-
Abstract:
Two new limonoids, 12-ethoxynimbolinins G and H (compounds 1 and 2), and one known compound, toosendanin (Chuanliansu) (compound 3), were isolated from the bark of Melia toosendan. Their structures were elucidated by spectroscopic analysis and X-ray techniques. The absolute configuration of toosendanin (3) was established by single-crystal X-ray diffraction. Compounds 1-3 were evaluated for their cytotoxicity against five tumor cell lines.
