Triterpenoid saponins from Patrinia scabra.
10.1016/S1875-5364(14)60008-X
- Author:
Feng FENG
1
,
2
;
Xi-Yu XU
3
;
Fu-Lei LIU
3
;
Wen-Yuan LIU
4
,
5
;
Ning XIE
6
Author Information
1. Department of Natural Products Chemistry, China Pharmaceutical University, Nanjing 210009, China
2. Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing, 210009, China. Electronic address: fengsunlight@163.com.
3. Department of Natural Products Chemistry, China Pharmaceutical University, Nanjing 210009, China.
4. Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, 210009, China
5. Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Ministry of Education, Nanjing 210009, China.
6. Qingfeng Pharmaceutical Inc., Ganzhou 341000, China.
- Publication Type:Journal Article
- Keywords:
Chemical constituents;
Cytotoxicity;
Patrinia scabra Bunge;
R284;
Triterpenoid saponins
- MeSH:
Cell Survival;
drug effects;
Drugs, Chinese Herbal;
chemistry;
toxicity;
Hep G2 Cells;
Humans;
Molecular Structure;
Patrinia;
chemistry;
Plant Roots;
chemistry;
Saponins;
chemistry;
toxicity;
Triterpenes;
chemistry;
toxicity
- From:
Chinese Journal of Natural Medicines (English Ed.)
2014;12(1):43-46
- CountryChina
- Language:English
-
Abstract:
AIM:To study the chemical constituents and bioactivity of the roots of Patrinia scabra Bunge.
METHODS:The chemical constituents were isolated using various chromatographic methods, and the structures were elucidated on the basis of spectral analysis and chemical methods. In addition, cytotoxic activities toward HepG2 cells were tested by the MTT method.
RESULTS:A new triterpenoid saponin, 3-O-(4'-isovaleryl)-O-β-D-xylose-12,30-dihydroxy-oleanane-28,13-lactone-22-O- β-D-glucoside (1), along with two known triterpenoid saponins, acanthopanax saponin CP3 (2) and foetoside C (3), were isolated.
CONCLUSION:The aglycone of compound 1 was a new skeleton derivative of oleanolic acid. Compound 2 showed strong cytotoxicity to HePG2 cells (IC50 1.49 μmol·L(-1)).
