Mixed nanomicelles loaded with thymopeptides-sodium deoxycholate/phospholipid improve drug absorption.
10.1016/S1875-5364(14)60011-X
- Author:
Shi-Xiao JIN
1
,
2
;
Shi-Ying JIN
1
,
2
;
Qing-Yuan LV
3
;
Shan-Shan FU
1
,
2
;
Jin HAN
4
;
Hai-Long YUAN
5
Author Information
1. Department of Pharmacy, 302 Military Hospital, Beijing 100039, China
2. School of pharmaceutics, Chengdu University of TCM, Chengdu 611730, China.
3. Department of Pharmacy, 302 Military Hospital, Beijing 100039, China.
4. Department of Pharmacy, 302 Military Hospital, Beijing 100039, China. Electronic address: hanjin302emba@163.com.
5. Department of Pharmacy, 302 Military Hospital, Beijing 100039, China. Electronic address: yhlpharm@126.com.
- Publication Type:Journal Article
- Keywords:
Immunodeficiency;
In situ intestinal absorption;
Micelles;
Phospholipid;
R283.6;
Sodium deoxycholate;
Thymopeptides
- MeSH:
Animals;
Chemistry, Pharmaceutical;
Deoxycholic Acid;
chemistry;
Drug Carriers;
chemistry;
Drug Stability;
Mice;
Micelles;
Particle Size;
Peptides;
administration & dosage;
chemistry;
pharmacokinetics;
Phospholipids;
chemistry;
Rats;
Rats, Wistar;
Thymus Gland;
chemistry
- From:
Chinese Journal of Natural Medicines (English Ed.)
2014;12(1):65-70
- CountryChina
- Language:English
-
Abstract:
AIM:To improve the absorption of thymopeptides (TH) by preparing sodium deoxycholate/phospholipid-mixed nanomicelles (SDC/PL-MMs).
METHODS:TH-SDC/PL-MMs were prepared by a film dispersion method, and then evaluated using photon correlation spectroscopy (PCS), zeta potential measurement, as well as their physical stability after storage for several days. Furthermore, in situ intestinal single-pass perfusion experiments and pharmacodynamics in immunodeficient mice were performed to make a comparison with TH powders and the control drug in absorption properties.
RESULTS:A narrow size distribution of nanomicelles, with a mean particle size of (149 ± 8.32) nm and a zeta potential of (-31.05 ± 2.52) mV, was obtained. The in situ intestine perfusion experiments demonstrated a significant advantage in absorption characteristics for TH compared to the other formulations, and oral administration of TH-SDC/PL-MMs potentiated an equivalent effect with i.h. TH in pharmacodynamic studies in immunodeficient mice.
CONCLUSIONS:TH-SDC/PL-MMs prepared by a film dispersion method are able to improve the absorption of TH. SDC/PL-MMs might be a good approach for the more effective delivery of drugs like TH.
