A new quinoline alkaloid from the roots of Dictamnus angustifolius.
10.1016/S1875-5364(14)60037-6
- Author:
Jian-Bo SUN
1
;
Wei QU
1
;
Fu-Qin GUAN
2
;
Lin-Zhen LI
1
;
Jing-Yu LIANG
3
Author Information
1. Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
2. Institute of Botany, Jiangsu Province and Chinese Academy of Science, Nanjing 210014, China.
3. Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China. Electronic address: jyliang08@126.com.
- Publication Type:Journal Article
- Keywords:
5-Methoxylrobustine;
Cytotoxicity;
Dictamnus angustifolius;
Quinoline alkaloids
- MeSH:
Antineoplastic Agents, Phytogenic;
isolation & purification;
pharmacology;
therapeutic use;
Breast Neoplasms;
drug therapy;
Cell Line, Tumor;
Dictamnus;
chemistry;
Humans;
Hydroxyquinolines;
chemistry;
isolation & purification;
pharmacology;
therapeutic use;
Molecular Structure;
Phytotherapy;
Plant Extracts;
chemistry;
pharmacology;
therapeutic use;
Plant Roots;
chemistry;
Quinolines;
chemistry;
isolation & purification;
pharmacology;
therapeutic use
- From:
Chinese Journal of Natural Medicines (English Ed.)
2014;12(3):222-224
- CountryChina
- Language:English
-
Abstract:
AIM:To investigate the quinoline alkaloids from the roots of Dictamnus angustifolius G.Don ex Sweet (Rutaceae).
METHOD:The quinoline alkaloids were isolated by various column chromatographic methods and their structures were elucidated on the basis of spectral analysis.
RESULTS:A new quinoline alkaloid, 5-methoxylrobustine (1), along with five known quinoline alkaloids were obtained, and their structures were identified as dictamnine (2), robustine (3), isopteleine (4), γ-fagarine (5), and skimmianine (6). Cytotoxicity testing of these alkaloids showed that all of them had weak cytotoxic activities against human breast cancer cells (MCF7).
CONCLUSION:Compound 1 is a new quinoline alkaloid. Alkaloid 3 showed stronger anti-proliferation effect than the other alkaloids.
