Chemical investigation of the roots of Polygala sibirica L.
10.1016/S1875-5364(14)60038-8
- Author:
Yu-Hong ZHOU
1
;
Shui-Ying ZHANG
2
;
Qiang GUO
2
;
Xing-Yun CHAI
2
;
Yong JIANG
3
;
Peng-Fei TU
4
,
5
Author Information
1. State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China.
2. Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.
3. State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China. Electronic address: yongjiang@bjmu.edu.cn.
4. State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China
5. Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China. Electronic address: pengfeitu@vip.163.com.
- Publication Type:Journal Article
- Keywords:
Polygala sibirica;
Polygalaceae;
Sibiricose A7;
Sibiriphenone A
- MeSH:
Benzophenones;
chemistry;
isolation & purification;
Coumaric Acids;
chemistry;
isolation & purification;
Glucosides;
chemistry;
isolation & purification;
Molecular Structure;
Plant Extracts;
chemistry;
Plant Roots;
chemistry;
Polygala;
chemistry;
Triterpenes;
chemistry;
isolation & purification;
Xanthones;
chemistry;
isolation & purification
- From:
Chinese Journal of Natural Medicines (English Ed.)
2014;12(3):225-228
- CountryChina
- Language:English
-
Abstract:
AIM:To investigate the chemical constituents of the roots of Polygala sibirica L. (Polygalaceae)
METHOD:The isolation was performed by solvent extraction and various chromatographic techniques, including silica gel, Sephadex LH-20, ODS, semi-preparative HPLC, and preparative TLC. The chemical structures were elucidated based on extensive spectroscopic analysis, including HR-ESI-MS and 1D- and 2D-NMR spectroscopic data.
RESULTS:A total of sixteen compounds, including five xanthones (5, 7-10), five saccharide esters (1, 3, 4, 12, 13), two flavonoids (14, 16), two triterpenoids (11, 15), one phenylpropanoid (6), and one benzophenone glycoside (2) were isolated. Their structures were determined as sibiricose A7 (1), sibiriphenone A (2), polygalatenoside A (3), polygalatenoside C (4), lancerin (5), 3, 4, 5-trimethoxycinnamic acid (6), 6-hydroxy-1, 2, 3, 7-tetramethoxyxanthone (7), 1, 3, 7-trihydroxy-2-methoxyxanthone (8), onjixanthone II (9), 1, 2, 3, 6, 7-pentamethoxyxanthone (10), presenegenin (11), 3'-O-3, 4, 5-trimethoxycinnamoyl-6-O-4-methoxy benzoyl sucrose (12), tenuifoliside C (13), 5, 3'-dihydroxy-7, 4'-dimethoxyflavonol-3-O-β-D-glucopyranoside (14), tenuifolin (15), and rhamnetin 3-O-β-D-glucopyranoside (16).
CONCLUSION:Compounds 1 and 2 are two new compounds from P. sibirica.
