Chemical constituents from the stems of Gymnema sylvestre.
10.1016/S1875-5364(14)60059-5
- Author:
Yue LIU
1
;
Tun-Hai XU
2
;
Man-Qi ZHANG
3
;
Xue LI
1
;
Ya-Juan XU
4
,
5
;
Hong-Yu JIANG
6
;
Tong-Hua LIU
2
;
Dong-Ming XU
1
Author Information
1. Jilin Academy of Chinese Medicine Sciences, Changchun 130012, China.
2. Department of Traditional Chinese Medicine Chemistry, School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100102, China.
3. School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
4. Jilin Academy of Chinese Medicine Sciences, Changchun 130012, China
5. School of Pharmacy, Jilin University, Changchun 130021, China. Electronic address: xyj6492@126.com.
6. Department of General Internal Medicine, The First Hospital of Jilin University, Jilin University, Changchun 130021, China. Electronic address: yh_zy5@163.com.
- Publication Type:Journal Article
- Keywords:
Gymnema sylvestre;
Non-enzymatic glycation-inhibiting activity;
Triterpenoid saponin
- MeSH:
Drugs, Chinese Herbal;
chemistry;
isolation & purification;
Gymnema sylvestre;
chemistry;
Molecular Structure;
Plant Stems;
chemistry
- From:
Chinese Journal of Natural Medicines (English Ed.)
2014;12(4):300-304
- CountryChina
- Language:English
-
Abstract:
AIM:To study the chemical constituents of stems of Gymnema sylvestre (Retz.) Schult.
METHODS:Chromatographic techniques using silica gel, C18 reversed phase silica gel, and prep-HPLC were used. The structures were elucidated on the basis of MS and spectroscopic analysis (1D and 2D NMR), as well as chemical methods.
RESULTS:Seven compounds were isolated and their structures were elucidated as conduritol A (1), stigmasterol (2), lupeol (3), stigmasterol-3-O-β-D-glucoside (4), the sodium salt of 22α-hydroxy-longispinogenin-3-O-β-D-glucopyranosyl-(1→3)-β-D-glu-curono-pyranosyl-28-O-α-L-rhamnopyranoside (5), oleanolic acid-3-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside (6), and the sodium salt of 22α-hydroxy-longispinogenin 3-O-β-D-glucuronopyranosyl-28-O-α-L-rhamnopyranoside (7). The inhibition activities of compounds 1, 5-7 on non-enzymatic glycation of protein in vitro were evaluated.
CONCLUSION:Compound 7 is a new triterpenoid saponin. It was shown that compounds 1, 5-7 have weak inhibition activities for non-enzymatic glycation of protein in vitro.
