Cause of Death in Korean Men with Prostate Cancer: an Analysis of Time Trends in a Nationwide Cohort.
10.3346/jkms.2016.31.11.1802
- Author:
Jinsung PARK
1
;
Beomseok SUH
;
Dong Wook SHIN
;
Jun Hyuk HONG
;
Hanjong AHN
Author Information
1. Department of Urology, Eulji University Hospital, Eulji University School of Medicine, Daejeon, Korea.
- Publication Type:Original Article
- Keywords:
Prostate Cancer;
Cause of Death;
Mortality;
Prostatectomy;
Radiation Therapy;
Androgen Deprivation Therapy
- MeSH:
Asian Continental Ancestry Group;
Cardiovascular Diseases;
Cause of Death*;
Cohort Studies*;
Follow-Up Studies;
Health Policy;
Humans;
Incidence;
Male;
Mortality;
National Health Programs;
Prostate*;
Prostatectomy;
Prostatic Neoplasms*;
Survivors
- From:Journal of Korean Medical Science
2016;31(11):1802-1807
- CountryRepublic of Korea
- Language:English
-
Abstract:
Despite rapid increase in incidence of prostate cancer (PC) and PC survivors, there are few studies regarding competing causes of death and time trends in Asian population. We conducted a cohort study of 2% nationwide random sample of Korean National Health Insurance employees. A total of 873 patients who had received active treatments, including surgery, radiation therapy (RT) and androgen deprivation therapy (ADT), for newly diagnosed PC between 2003 and 2010 were included. The cause of death was categorized as PC, other cancers, cardiovascular disease, and other causes. During a median follow-up of 4.75 years, 29.4% (257/873) of the study population died. PC, other cancers, cardiovascular disease, and other causes were responsible for 46.3%, 35.4%, 6.6%, and 11.7%, respectively, of the decedents. Significant differences existed in the cause of death among treatment groups (P < 0.001). Only 20% and 9.5% of surgery and RT group died of PC, whereas 63.9% of ADT group died of PC. Other cancers were responsible for 56%, 74.6% and 17.8% of death in the surgery, RT and ADT group, respectively, while cardiovascular disease accounted for 4%, 6.3%, and 7.1% of death in the treatment groups. Analysis of time trends showed that PC-specific death tended to decrease (from 42.9% in 2003 to 23.1% in 2010), whereas non-PC causes tended to increase over the 8 years. Our results are valuable in overviewing causes of death and time trends in Korean PC patients, and planning future health policy for PC.
